cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster
about
The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressPhosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damageThe human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilonRetention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damageReconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complexClamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC.Cancer models in Caenorhabditis elegans.Downregulation of Hus1 by antisense oligonucleotides enhances the sensitivity of human lung carcinoma cells to cisplatin.DNA-damage-induced checkpoint pathways in the nematode Caenorhabditis elegans.Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stressRegulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment.Transcriptional regulation of the Drosophila rfc1 gene by the DRE-DREF pathway.Mutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control.MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans.Application of hRad9 in lung cancer treatment as a molecular marker and a molecular target.Close head-to-head juxtaposition of genes favors their coordinate regulation in Drosophila melanogaster.
P2860
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P2860
cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster
description
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
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im Dezember 1998 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 1998/12/15)
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vědecký článek publikovaný v roce 1998
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wetenschappelijk artikel (gepubliceerd op 1998/12/15)
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наукова стаття, опублікована в грудні 1998
@uk
научни чланак (објављен 1998/12/15)
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name
cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
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cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
@en
cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
@nl
type
label
cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
@ast
cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
@en
cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
@nl
prefLabel
cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
@ast
cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
@en
cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
@nl
P356
P1433
P1476
cDNA cloning and gene mapping ...... s, and Drosophila melanogaster
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P2093
P304
P356
10.1006/GENO.1998.5587
P407
P577
1998-12-15T00:00:00Z