Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage
about
The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damageProtein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CADInteraction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cellsInteraction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingLong patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complexRegulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatinHuman RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaksCharacterization of DNA damage-stimulated self-interaction of Saccharomyces cerevisiae checkpoint protein Rad17p.Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complexATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responsesStructures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopyA role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complexRecruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phaseThe Fanconi anemia core complex forms four complexes of different sizes in different subcellular compartmentsThe role of checkpoint kinase 1 in sensitivity to topoisomerase I poisonsMutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombinationFanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner.Cloning and characterization of MDDX28, a putative dead-box helicase with mitochondrial and nuclear localization.Rad9 modulates the P21WAF1 pathway by direct association with p53.Fission yeast Rad17 associates with chromatin in response to aberrant genomic structuresATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein.Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding.Phosphorylation of Rad9 at serine 328 by cyclin A-Cdk2 triggers apoptosis via interfering Bcl-xLPhosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminusWhen repair meets chromatin. First in series on chromatin dynamicsHuman RAD9 checkpoint control/proapoptotic protein can activate transcription of p21.DNA damage and autophagy.The role of RAD9 in tumorigenesis.Two checkpoint complexes are independently recruited to sites of DNA damage in vivo.Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutantsThe human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repairGenome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repairXRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus.DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extractsLysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.
P2860
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P2860
Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage
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2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2000 թվականի օգոստոսին հրատարակված գիտական հոդված
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2000年の論文
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Retention of the human Rad9 ch ...... ear complexes after DNA damage
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Retention of the human Rad9 ch ...... ear complexes after DNA damage
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Retention of the human Rad9 ch ...... ear complexes after DNA damage
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Retention of the human Rad9 ch ...... ear complexes after DNA damage
@ast
Retention of the human Rad9 ch ...... ear complexes after DNA damage
@en
Retention of the human Rad9 ch ...... ear complexes after DNA damage
@nl
prefLabel
Retention of the human Rad9 ch ...... ear complexes after DNA damage
@ast
Retention of the human Rad9 ch ...... ear complexes after DNA damage
@en
Retention of the human Rad9 ch ...... ear complexes after DNA damage
@nl
P2093
P2860
P356
P1476
Retention of the human Rad9 ch ...... ear complexes after DNA damage
@en
P2093
L M Karnitz
M A Burtelow
S H Kaufmann
P2860
P304
P356
10.1074/JBC.M001244200
P407
P577
2000-08-25T00:00:00Z