The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases
about
Mutational activation of the MAP3K8 protooncogene in lung cancerThe tyrosine kinase Syk regulates TPL2 activation signalsNF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activityMeaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsOpposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cellsAkt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activationShared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalphaMixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complexMultiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformationThe COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activityThe oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerNF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic ImplicationsCOT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activationASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interactionUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingIdentification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signalingEffects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinaseComparison of peptide array substrate phosphorylation of c-Raf and mitogen activated protein kinase kinase kinase 8Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines.Functional genomic delineation of TLR-induced transcriptional networks.Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cellsPersistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions.NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase.An enigmatic tail of CD28 signaling.Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathwaysIntestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.A CD4+ T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function.A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.T lymphocyte activation--an inside overview.Changes in gene expression profiles in developing B cells of murine bone marrowNF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-thetaRaf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation.Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.Loss of NDRG2 enhanced activation of the NF-κB pathway by PTEN and NIK phosphorylation for ATL and other cancer development.Aberrant expression of COT is related to recurrence of papillary thyroid cancer.
P2860
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P2860
The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@ast
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@en
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@nl
type
label
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@ast
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@en
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@nl
prefLabel
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@ast
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@en
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@nl
P2093
P3181
P1433
P1476
The proto-oncogene Cot kinase ...... ing kinase and IkappaB kinases
@en
P2093
P304
P3181
P356
10.1016/S1074-7613(00)80027-8
P407
P577
1999-02-01T00:00:00Z