Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2
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A predicted amphipathic helix mediates plasma membrane localization of GRK5Phosphorylation-independent desensitization of GABA(B) receptor by GRK4The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers.Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor KinasesStrike a pose: Gαq complexes at the membraneG protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation.G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function.Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3.Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays.Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits.Molecular modeling of the membrane targeting of phospholipase C pleckstrin homology domains.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerPhosphorylation-independent desensitization of G protein-coupled receptors?G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane.Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and GβγG Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro.Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo.Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed InhibitorThe evolving impact of g protein-coupled receptor kinases in cardiac health and diseaseStructural and functional determinants of conserved lipid interaction domains of inward rectifying Kir6.2 channelsContributions of protein kinases and β-arrestin to termination of protease-activated receptor 2 signaling.Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site.Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylationDetection of the endogenous mu opioid receptor (mopr) in brainA common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability.Structural insights into G protein-coupled receptor kinase function.Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitizationEGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation.G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels.Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits.PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activationG protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunitsGbetagamma-dependent and Gbetagamma-independent basal activity of G protein-activated K+ channels.Dopamine negatively modulates the NCA ion channels in C. elegans.Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-Gβ1γ2 Complex
P2860
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P2860
Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@ast
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@en
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@nl
type
label
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@ast
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@en
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@nl
prefLabel
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@ast
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@en
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@nl
P2093
P356
P1476
Mutational analysis of Gbetaga ...... tein-coupled receptor kinase 2
@en
P2093
J J Onorato
J L Benovic
L Y Liu-Chen
S P Kennedy
P304
10443-10452
P356
10.1074/JBC.275.14.10443
P407
P577
2000-04-01T00:00:00Z