Control of electrical activity in central neurons by modulating the gating of small conductance Ca2+-activated K+ channels
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Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channelsThe riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.A helical region in the C terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulinIdentification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channelsUnexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferationFunctions of SK channels in central neuronsCa(2+)-activated K+ channels: molecular determinants and function of the SK familyModulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson's disease?Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.Formation of cellular projections in neural progenitor cells depends on SK3 channel activitySK2 channel expression and function in cerebellar Purkinje cellsPharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1)Calcium-dependent control of temporal processing in an auditory interneuron: a computational analysisChronic stress causes amygdala hyperexcitability in rodents.Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone ratSK2 channels are neuroprotective for ischemia-induced neuronal cell deathNaphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressureMolecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.An SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesis.Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia.New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia.SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels.Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes.Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses.Characterization of an apamin-sensitive small-conductance Ca(2+)-activated K(+) channel in porcine coronary artery endothelium: relevance to EDHFCharybdotoxin-sensitive small conductance K(Ca) channel activated by bradykinin and substance P in endothelial cells.Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF.Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slicesSK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes.Calcium-activated potassium channels: multiple contributions to neuronal function.CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate.Mechanistic details of BK channel inhibition by the intermediate conductance, Ca2+-activated K channel.In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning.Therapeutic potential of KCa3.1 blockers: recent advances and promising trends.Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?Prolonging the postcomplex spike pause speeds eyeblink conditioning.Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons
P2860
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P2860
Control of electrical activity in central neurons by modulating the gating of small conductance Ca2+-activated K+ channels
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Control of electrical activity ...... nce Ca2+-activated K+ channels
@ast
Control of electrical activity ...... nce Ca2+-activated K+ channels
@en
Control of electrical activity ...... nce Ca2+-activated K+ channels
@nl
type
label
Control of electrical activity ...... nce Ca2+-activated K+ channels
@ast
Control of electrical activity ...... nce Ca2+-activated K+ channels
@en
Control of electrical activity ...... nce Ca2+-activated K+ channels
@nl
prefLabel
Control of electrical activity ...... nce Ca2+-activated K+ channels
@ast
Control of electrical activity ...... nce Ca2+-activated K+ channels
@en
Control of electrical activity ...... nce Ca2+-activated K+ channels
@nl
P2093
P356
P1476
Control of electrical activity ...... nce Ca2+-activated K+ channels
@en
P2093
J Mosbacher
J P Adelman
L A Cingolani
P Pedarzani
P304
P356
10.1074/JBC.M010001200
P407
P577
2001-03-30T00:00:00Z