beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation - Wikidata - awgldk - TriplyDB

beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation

beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation

http://www.wikidata.org/entity/Q28144504

about

Dishevelled and Wnt signaling: is the nucleus the final frontier?beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members.Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer Wnt signaling: the good and the bad Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling Molecular specification of germ layers in vertebrate embryos The many faces and functions of β-catenin Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon The β-catenin destruction complex Custos controls β-catenin to regulate head development during vertebrate embryogenesis Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis.F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction.Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling Mutation of Vav1 adaptor region reveals a new oncogenic activation.Associations Among -TrCP, an E3 Ubiquitin Ligase Receptor, -Catenin, and NF- B in Colorectal Cancer Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis Complete functional segregation of planarian beta-catenin-1 and -2 in mediating Wnt signaling and cell adhesion.CCL2 disrupts the adherens junction: implications for neuroinflammation Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner.Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase

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beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation

http://www.wikidata.org/entity/Q28144504

description

1999 nî lūn-bûn

@nan

1999 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի մայիսին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@ast

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@en

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@nl

type

label

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@ast

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@en

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@nl

prefLabel

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@ast

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@en

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@nl

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PNAS.96.11.6273

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Proceedings of the National Academy of Sciences of the United States of America

P1476

beta-Trcp couples beta-catenin ...... gulates Xenopus axis formation

@en

P2093

B A Yankner

http://www.w3.org/2001/XMLSchema#string

C Liu

http://www.w3.org/2001/XMLSchema#string

V M Do

http://www.w3.org/2001/XMLSchema#string

X He

http://www.w3.org/2001/XMLSchema#string

Y Kato

http://www.w3.org/2001/XMLSchema#string

Z Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Ubiquitin-dependent protein degradation

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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6273-8

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scholarly article

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10.1073/PNAS.96.11.6273

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11

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96

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1999-05-25T00:00:00Z

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P5875

12958443

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10339577

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P921

phosphorylation

P932

26871

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