Mechanism of decarboxylation of 1,3-dimethylorotic acid. A model for orotidine 5'-phosphate decarboxylase
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Anatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analogElectrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylaseThe crystal structure and mechanism of orotidine 5'-monophosphate decarboxylaseA proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylaseMechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.The stability of aryl carbanions derived from pyridine N-oxide: the role of resonance in stabilizing aryl anions.Convenient synthesis of N1-substituted orotic acid derivativesAccelerated hydrolysis of α-halo and α-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMPQM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysisPolarization in the structures of uracil and thiouracils: Implication for binding with orotidine 5'-monophosphate decarboxylaseHydrolysis of α-chloro-substituted 2- and 4-pyridones: rate enhancement by zwitterionic structure.Selection of catalytic antibodies for a biosynthetic reaction from a combinatorial cDNA library by complementation of an auxotrophic Escherichia coli: antibodies for orotate decarboxylation.Using catalytic atom maps to predict the catalytic functions present in enzyme active sites.Improved synthesis of N1-substituted orotic acid derivatives.Stabilities of Uracil and Pyridone-Based Carbanions: A Systematic Study in the Gas Phase and Solution and Implications for the Mechanism of Orotidine-5'-Monophosphate Decarboxylase.Development and application of ab initio QM/MM methods for mechanistic simulation of reactions in solution and in enzymes.Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.Stability of the 6-carbanion of uracil analogues: mechanistic implications for model reactions of orotidine-5'-monophosphate decarboxylase.Orotic acid decarboxylation in water and nonpolar solvents: a potential role for desolvation in the action of OMP decarboxylase.Carbanions from decarboxylation of orotate analogs: stability and mechanistic implicationsCatalysis in Enzymatic Decarboxylations: Comparison of Selected Cofactor-dependent and Cofactor-independent Examples.Design of inhibitors of ODCase.The acidity of uracil and uracil analogs in the gas phase: four surprisingly acidic sites and biological implications.The gas phase proton affinity of uracil: measuring multiple basic sites and implications for the enzyme mechanism of orotidine 5'-monophosphate decarboxylase.
P2860
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P2860
Mechanism of decarboxylation of 1,3-dimethylorotic acid. A model for orotidine 5'-phosphate decarboxylase
description
1976 nî lūn-bûn
@nan
1976 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1976 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1976年の論文
@ja
1976年論文
@yue
1976年論文
@zh-hant
1976年論文
@zh-hk
1976年論文
@zh-mo
1976年論文
@zh-tw
1976年论文
@wuu
name
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@ast
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@en
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@nl
type
label
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@ast
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@en
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@nl
prefLabel
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@ast
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@en
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@nl
P356
P1476
Mechanism of decarboxylation o ...... ine 5'-phosphate decarboxylase
@en
P304
P356
10.1021/JA00428A035
P407
P577
1976-06-09T00:00:00Z