A proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylase
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Anatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analogElectrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylaseThe crystal structure and mechanism of orotidine 5'-monophosphate decarboxylaseMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding SiteConformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the EnzymeObservation of a stable carbene at the active site of a thiamin enzymeMechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.The stability of aryl carbanions derived from pyridine N-oxide: the role of resonance in stabilizing aryl anions.Molecular dynamic study of orotidine-5'-monophosphate decarboxylase in ground state and in intermediate state: a role of the 203-218 loop dynamics.On catalytic preorganization in oxyanion holes: highlighting the problems with the gas-phase modeling of oxyanion holes and illustrating the need for complete enzyme models.Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution.Convenient synthesis of N1-substituted orotic acid derivativesQM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysisPolarization in the structures of uracil and thiouracils: Implication for binding with orotidine 5'-monophosphate decarboxylaseMechanisms and free energies of enzymatic reactions.Computer simulations of enzyme catalysis: finding out what has been optimized by evolution.Using catalytic atom maps to predict the catalytic functions present in enzyme active sites.Free energies of chemical reactions in solution and in enzymes with ab initio quantum mechanics/molecular mechanics methodsImproved synthesis of N1-substituted orotic acid derivatives.Stabilities of Uracil and Pyridone-Based Carbanions: A Systematic Study in the Gas Phase and Solution and Implications for the Mechanism of Orotidine-5'-Monophosphate Decarboxylase.Development and application of ab initio QM/MM methods for mechanistic simulation of reactions in solution and in enzymes.Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.Stability of the 6-carbanion of uracil analogues: mechanistic implications for model reactions of orotidine-5'-monophosphate decarboxylase.An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organismsCarbanions from decarboxylation of orotate analogs: stability and mechanistic implicationsCatalysis in Enzymatic Decarboxylations: Comparison of Selected Cofactor-dependent and Cofactor-independent Examples.Design of inhibitors of ODCase.Simulating enzyme reactions: challenges and perspectives.Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants.The acidity of uracil and uracil analogs in the gas phase: four surprisingly acidic sites and biological implications.The gas phase proton affinity of uracil: measuring multiple basic sites and implications for the enzyme mechanism of orotidine 5'-monophosphate decarboxylase.Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites.
P2860
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P2860
A proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylase
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@ast
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@en
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@nl
type
label
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@ast
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@en
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@nl
prefLabel
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@ast
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@en
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@nl
P2860
P1433
P1476
A proficient enzyme revisited: ...... ne monophosphate decarboxylase
@en
P2093
P2860
P356
10.1126/SCIENCE.276.5314.942
P407
P50
P577
1997-05-09T00:00:00Z