Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
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A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated agingWRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication forkDNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchangePRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryFunctional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damageMinichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinasesHomologous recombination in DNA repair and DNA damage toleranceThe Role of PCNA Posttranslational Modifications in Translesion SynthesisReplication protein A-mediated recruitment and activation of Rad17 complexesThe replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationPolymerase dynamics at the eukaryotic DNA replication forkHuman RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication forkMus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiaeLimited TTP supply affects telomere length regulation in a telomerase-independent fashionBiochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNADNA damage tolerance by recombination: Molecular pathways and DNA structuresManaging Single-Stranded DNA during Replication Stress in Fission YeastInhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyRescuing stalled or damaged replication forksMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeA structure-specific nucleic acid-binding domain conserved among DNA repair proteinsActivation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a.Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.Mcm2 phosphorylation and the response to replicative stressSeparate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.Identification of protein complexes required for efficient sister chromatid cohesion.Elg1 forms an alternative RFC complex important for DNA replication and genome integrityYeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression.Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage.Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity.An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo.A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast.Genome-wide localization of Rrm3 and Pif1 DNA helicases at stalled active and inactive DNA replication forks of Saccharomyces cerevisiae.Evidence that a RecQ helicase slows senescence by resolving recombining telomeres
P2860
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P2860
Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
description
2002 nî lūn-bûn
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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@ast
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@en
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@nl
type
label
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@ast
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@en
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@nl
prefLabel
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@ast
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@en
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@nl
P3181
P356
P1433
P1476
Fork reversal and ssDNA accumu ...... ks owing to checkpoint defects
@en
P2093
José M Sogo
P304
P3181
P356
10.1126/SCIENCE.1074023
P407
P577
2002-07-26T00:00:00Z