Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation
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STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influxSTIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channelsDynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel componentsSTIM proteins: dynamic calcium signal transducersCoupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum.STIM1, an essential and conserved component of store-operated Ca2+ channel functionStructural aspects of calcium-release activated calcium channel functionOrai3--the 'exceptional' Orai?Molecular regulation of CRAC channels and their role in lymphocyte functionRegulation of STIM1 and SOCE by the ubiquitin-proteasome system (UPS)Age and diet affect gene expression profile in canine skeletal muscleMapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activationPhospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cellsAnimal Ca2+ release-activated Ca2+ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitators.Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.STIMulating store-operated Ca(2+) entry.Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.CRAC channelopathies.STIM proteins and the endoplasmic reticulum-plasma membrane junctions.Visualisation and identification of the interaction between STIM1s in resting cells.Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells.Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels.Formation of STIM and Orai complexes: puncta and distal caps.STIM and Orai: the long-awaited constituents of store-operated calcium entryTRPC channels in smooth muscle cellsStim and Orai proteins in neuronal Ca(2+) signaling and excitabilitySTIM and Orai proteins and the non-capacitative ARC channels.Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating.Recent breakthroughs in the molecular mechanism of capacitative calcium entry (with thoughts on how we got here)STIM1 and the noncapacitative ARC channels.New molecular players in capacitative Ca2+ entry.Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.Novel compartment implicated in calcium signaling--is it an "induced coupling domain"?A plasma membrane-targeted cytosolic domain of STIM1 selectively activates ARC channels, an arachidonate-regulated store-independent Orai channelTranscriptional basis of lymphocyte tolerance.Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1STIM1fl/fl Ksp-Cre Mouse has Impaired Renal Water BalanceOligomerization of STIM1 couples ER calcium depletion to CRAC channel activationSTIM proteins: integrators of signalling pathways in development, differentiation and disease.
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P2860
Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation
description
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im April 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: April 2002)
@en
vedecký článok (publikovaný 2002/04/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/04/01)
@nl
наукова стаття, опублікована у квітні 2002
@uk
مقالة علمية (نشرت في أبريل 2002)
@ar
name
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@ast
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@en
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@nl
type
label
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@ast
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@en
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@nl
prefLabel
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@ast
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@en
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@nl
P2093
P1476
Stromal interaction molecule 1 ...... fied by N-linked glycosylation
@en
P2093
Judith E Layton
Leonie Van Stekelenburg
Marie A Dziadek
Paul V Senior
Peter J Smith
Richard T Williams
P356
10.1016/S0167-4838(02)00211-X
P407
P577
2002-04-01T00:00:00Z