Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe
about
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)Current approaches for the discovery of drugs that deter substance and drug abuse.All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium.Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges.Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypesA Simple Representation of Three-Dimensional Molecular Structure.Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies.
P2860
Q28246512-A35F1F05-B87B-42F5-858E-0B1AA3BE4AF4Q28973615-F4DE9822-00AD-45D3-98F3-1B32864560EFQ33895150-723D7B4F-2770-4415-8C89-01FC3CA062EAQ35534556-CE0F6F26-BACC-42BB-BCC9-6D919339B156Q35602706-41E0484C-BDB6-473D-9B19-04D84E645C75Q36098318-236ABBAD-1B52-4FEF-AD8E-7850DCB4B7AAQ45946583-A8AF0C23-D29A-4DC7-8E37-F74B893DB3B5Q46379917-420DF2F9-2ABD-4A49-A5CE-50350DA47D7DQ50872293-555A9B3C-9DEF-4989-BA75-C9EF69B5070B
P2860
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe
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2014 nî lūn-bûn
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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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Discovery, synthesis and chara ...... L381): a novel molecular probe
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Discovery, synthesis and chara ...... L381): a novel molecular probe
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Discovery, synthesis and chara ...... L381): a novel molecular probe
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label
Discovery, synthesis and chara ...... L381): a novel molecular probe
@ast
Discovery, synthesis and chara ...... L381): a novel molecular probe
@en
Discovery, synthesis and chara ...... L381): a novel molecular probe
@nl
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Discovery, synthesis and chara ...... L381): a novel molecular probe
@ast
Discovery, synthesis and chara ...... L381): a novel molecular probe
@en
Discovery, synthesis and chara ...... L381): a novel molecular probe
@nl
P2093
P2860
P50
P356
P1433
P1476
Discovery, synthesis and chara ...... L381): a novel molecular probe
@en
P2093
Anuruddha Rajapakse
Emery Smith
Frank Byers
Hyekyung P Cho
J Scott Daniels
Masaya Kokubo
Michael R Wood
Patrick R Gentry
Peter Chase
Peter S Hodder
P2860
P304
P356
10.1002/CMDC.201402051
P407
P577
2014-08-01T00:00:00Z