Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

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http://www.wikidata.org/entity/Q28237300
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)Current approaches for the discovery of drugs that deter substance and drug abuse.All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium.Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges.Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypesA Simple Representation of Three-Dimensional Molecular Structure.Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies.
P2860

Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

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http://www.wikidata.org/entity/Q28237300
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2014 nî lūn-bûn
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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Discovery, synthesis and chara ...... L381): a novel molecular probe
@ast
Discovery, synthesis and chara ...... L381): a novel molecular probe
@en
Discovery, synthesis and chara ...... L381): a novel molecular probe
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Discovery, synthesis and chara ...... L381): a novel molecular probe
@ast
Discovery, synthesis and chara ...... L381): a novel molecular probe
@en
Discovery, synthesis and chara ...... L381): a novel molecular probe
@nl
prefLabel
Discovery, synthesis and chara ...... L381): a novel molecular probe
@ast
Discovery, synthesis and chara ...... L381): a novel molecular probe
@en
Discovery, synthesis and chara ...... L381): a novel molecular probe
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Discovery, synthesis and chara ...... L381): a novel molecular probe
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932