Discovery of ML326: The first sub-micromolar, selective M5 PAM - Wikidata - awgldk - TriplyDB

Discovery of ML326: The first sub-micromolar, selective M5 PAM

Discovery of ML326: The first sub-micromolar, selective M5 PAM

http://www.wikidata.org/entity/Q28288485

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)Current approaches for the discovery of drugs that deter substance and drug abuse.Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges.

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Discovery of ML326: The first sub-micromolar, selective M5 PAM

http://www.wikidata.org/entity/Q28288485

description

2013 nî lūn-bûn

@nan

2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

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name

Discovery of ML326: The first sub-micromolar, selective M5 PAM

@ast

Discovery of ML326: The first sub-micromolar, selective M5 PAM

@en

Discovery of ML326: The first sub-micromolar, selective M5 PAM

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type

label

Discovery of ML326: The first sub-micromolar, selective M5 PAM

@ast

Discovery of ML326: The first sub-micromolar, selective M5 PAM

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Discovery of ML326: The first sub-micromolar, selective M5 PAM

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prefLabel

Discovery of ML326: The first sub-micromolar, selective M5 PAM

@ast

Discovery of ML326: The first sub-micromolar, selective M5 PAM

@en

Discovery of ML326: The first sub-micromolar, selective M5 PAM

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J.BMCL.2013.03.032

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Bioorganic & Medicinal Chemistry Letters

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Discovery of ML326: The first sub-micromolar, selective M5 PAM

@en

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Atin Lamsal

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Emery Smith

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J Scott Daniels

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Julie L Engers

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Michael R Wood

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Paige N Vinson

http://www.w3.org/2001/XMLSchema#string

Patrick R Gentry

http://www.w3.org/2001/XMLSchema#string

Peter Chase

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Peter S Hodder

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Thomas M Bridges

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Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

Identification of a family of muscarinic acetylcholine receptor genes

Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

The antipsychotic potential of muscarinic allosteric modulation

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia

Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice.

M₅ muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice.

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2996-3000

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scholarly article

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10.1016/J.BMCL.2013.03.032

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P433

10

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23

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Colleen M. Niswender

Craig W. Lindsley

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2013-05-15T00:00:00Z

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236126798

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23562060

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Aagianik kimischri

clinical chemistry

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3634896

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