Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)

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http://www.wikidata.org/entity/Q35602706
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrateIdentification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes InsipidusDiscovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine coreOptimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.Overview of Critical Parameters for the Design and Execution of a High-Throughput Screen for Allosteric Ligands.Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core.Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.
P2860

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)

Item
http://www.wikidata.org/entity/Q35602706
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
@zh-tw
2015年论文
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2015年论文
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2015年论文
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name
Application of Parallel Multip ...... Acetylcholine Receptor 4 (M4)
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Application of Parallel Multip ...... Acetylcholine Receptor 4 (M4)
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type
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Application of Parallel Multip ...... Acetylcholine Receptor 4 (M4)
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Application of Parallel Multip ...... Acetylcholine Receptor 4 (M4)
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prefLabel
Application of Parallel Multip ...... Acetylcholine Receptor 4 (M4)
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Application of Parallel Multip ...... Acetylcholine Receptor 4 (M4)
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P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932
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P1433
P1476
Application of Parallel Multip ...... Acetylcholine Receptor 4 (M4)
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P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932