Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome
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DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinaseConcise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic diseaseDown syndrome: searching for the genetic culpritsThe kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation siteThe kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinaseDYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 bindingRegulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationActivation of androgen receptor function by a novel nuclear protein kinaseOverexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosomeCharacterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factorsDynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrateIdentification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1ACloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brainDyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter releaseDYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in micePhosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.Bacterial artificial chromosome libraries for mouse sequencing and functional analysis.Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1.Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A).Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.Brain waves and brain wiring: the role of endogenous and sensory-driven neural activity in development.C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.Role for YakA, cAMP, and protein kinase A in regulation of stress responses of Dictyostelium discoideum cellsAn aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.Roles of the DYRK kinase Pom2 in cytokinesis, mitochondrial morphology, and sporulation in fission yeast.Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndromeThe transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A.Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells.Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus.A new method for generating point mutations in bacterial artificial chromosomes by homologous recombination in Escherichia coli.REST regulates DYRK1A transcription in a negative feedback loop.NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effectPhosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)
P2860
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P2860
Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Functional screening of 2 Mb o ...... associated with Down syndrome
@ast
Functional screening of 2 Mb o ...... associated with Down syndrome
@en
Functional screening of 2 Mb o ...... associated with Down syndrome
@nl
type
label
Functional screening of 2 Mb o ...... associated with Down syndrome
@ast
Functional screening of 2 Mb o ...... associated with Down syndrome
@en
Functional screening of 2 Mb o ...... associated with Down syndrome
@nl
prefLabel
Functional screening of 2 Mb o ...... associated with Down syndrome
@ast
Functional screening of 2 Mb o ...... associated with Down syndrome
@en
Functional screening of 2 Mb o ...... associated with Down syndrome
@nl
P2093
P2860
P356
P1433
P1476
Functional screening of 2 Mb o ...... associated with Down syndrome
@en
P2093
A M Watabe
M E Stevens
M Makhinson
R T Bronson
S P Sudanagunta
P2860
P2888
P356
10.1038/NG0597-28
P407
P577
1997-05-01T00:00:00Z