Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"
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The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation siteThe kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinaseMirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alphaRegulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationYak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal.Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrateFunctional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndromeDyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in micePhosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration.Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A).Distinctive Phenotypic Abnormalities Associated with Submicroscopic 21q22 Deletion Including DYRK1A.A de novo convergence of autism genetics and molecular neuroscience.Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammalsAssociation study of candidate gene polymorphisms with amnestic mild cognitive impairment in a Chinese populationThe role of DYRK1A in neurodegenerative diseases.NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effectLink between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndromeTransient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling.p53 downregulates Down syndrome-associated DYRK1A through miR-1246.Trisomy 21 and early brain developmentTrisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndromeDown's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathwayDYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies.A rare de novo duplication of chromosome 21q22.12 → q22.3 with other concomitant deletion and duplication of small fragments in 21q associated with Down syndrome: Prenatal diagnosis, molecular cytogenetic characterizationOverexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome.The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome.Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells.Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21.MNB/DYRK1A as a multiple regulator of neuronal development.Is it possible to improve neurodevelopmental abnormalities in Down syndrome?Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?DYRK1A inhibition as potential treatment for Alzheimer's disease.DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis.Autism genetics - an overview.Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets.Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.
P2860
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P2860
Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Isolation of human and murine ...... own syndrome "critical region"
@ast
Isolation of human and murine ...... own syndrome "critical region"
@en
Isolation of human and murine ...... own syndrome "critical region"
@en-gb
Isolation of human and murine ...... own syndrome "critical region"
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type
label
Isolation of human and murine ...... own syndrome "critical region"
@ast
Isolation of human and murine ...... own syndrome "critical region"
@en
Isolation of human and murine ...... own syndrome "critical region"
@en-gb
Isolation of human and murine ...... own syndrome "critical region"
@nl
prefLabel
Isolation of human and murine ...... own syndrome "critical region"
@ast
Isolation of human and murine ...... own syndrome "critical region"
@en
Isolation of human and murine ...... own syndrome "critical region"
@en-gb
Isolation of human and murine ...... own syndrome "critical region"
@nl
P2093
P356
P1433
P1476
Isolation of human and murine ...... own syndrome "critical region"
@en
P2093
C Kasten-Sportès
D E Miller
D M Kurnit
L R Sternberg
M L Keuren
P W Chiang
T W Glover
P356
10.1006/GENO.1996.0636
P407
P577
1996-12-15T00:00:00Z