Selecting effective antisense reagents on combinatorial oligonucleotide arrays
about
Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymesPredicting oligonucleotide affinity to nucleic acid targets.Sfold web server for statistical folding and rational design of nucleic acidsProfiled support vector machines for antisense oligonucleotide efficacy predictionMorpholino antisense oligonucleotides: tools for investigating vertebrate development.Silencing disease genes in the laboratory and the clinicMapping of RNA accessible sites by extension of random oligonucleotide libraries with reverse transcriptase.Determination of optimal sites of antisense oligonucleotide cleavage within TNFalpha mRNA.A rapid genetic screening system for identifying gene-specific suppression constructs for use in human cells.HIV-1 LTR as a target for synthetic ribozyme-mediated inhibition of gene expression: site selection and inhibition in cell culturemRNA accessible site tagging (MAST): a novel high throughput method for selecting effective antisense oligonucleotidesMicroRNAs align with accessible sites in target mRNAs.Structural rearrangements in RNA on the binding of an antisense oligonucleotide: implications for the study of intra-molecular RNA interactions and the design of cooperatively acting antisense reagents with enhanced efficacy.A genomic selection strategy to identify accessible and dimerization blocking targets in the 5'-UTR of HIV-1 RNASelection of antisense oligonucleotides based on multiple predicted target mRNA structures.A structural analysis of in vitro catalytic activities of hammerhead ribozymes.Feasibility of transferring fluorescent in situ hybridization probes to an 18S rRNA gene phylochip and mapping of signal intensities.Improvement of RNA secondary structure prediction using RNase H cleavage and randomized oligonucleotides.Functional analysis of newly discovered growth control genes: experimental approaches.Mutational analysis using oligonucleotide microarrays.Controlling the mitochondrial gatekeeper for effective chemotherapy.Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNAMapping targetable sites on human telomerase RNA pseudoknot/template domain using 2'-OMe RNA-interacting polynucleotide (RIPtide) microarrays.Molecular and cellular barriers limiting the effectiveness of antisense oligonucleotides.Prioritized selection of oligodeoxyribonucleotide probes for efficient hybridization to RNA transcriptsIsoenergetic penta- and hexanucleotide microarray probing and chemical mapping provide a secondary structure model for an RNA element orchestrating R2 retrotransposon protein functionA rapid in vitro method for obtaining RNA accessibility patterns for complementary DNA probes: correlation with an intracellular pattern and known RNA structuresThe effect of structure in a long target RNA on ribozyme cleavage efficiency.Microarrays for identifying binding sites and probing structure of RNAsVariables and strategies in development of therapeutic post-transcriptional gene silencing agentsRational design and rapid screening of antisense oligonucleotides for prokaryotic gene modulation.The potential of antisense as a CNS therapeutic.The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides.RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNAIn vitro selection of a purine nucleotide-specific hammerheadlike ribozyme.Metal phosphonates applied to biotechnologies: a novel approach to oligonucleotide microarrays.Fundamental differences in the equilibrium considerations for siRNA and antisense oligodeoxynucleotide designBinding of a structured D-RNA molecule by an L-RNA aptamer.An intelligent approach to the discovery of luminescent materials using a combinatorial approach combined with Taguchi methodology.Design and development of antisense drugs.
P2860
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P2860
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@ast
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@en
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@nl
type
label
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@ast
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@en
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@nl
prefLabel
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@ast
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@en
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@nl
P2093
P356
P1433
P1476
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
@en
P2093
P2888
P304
P356
10.1038/NBT0697-537
P407
P577
1997-06-01T00:00:00Z