Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia
about
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcriptionMCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcriptionInfertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemiaCell and tumor classification using gene expression data: construction of forests.Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms.Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocationMLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomLAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia.MLL fusion partners AF4 and AF9 interact at subnuclear foci.Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins.A screen for modifiers of decapentaplegic mutant phenotypes identifies lilliputian, the only member of the Fragile-X/Burkitt's Lymphoma family of transcription factors in Drosophila melanogasterPremature transcript termination, trans-splicing and DNA repair: a vicious path to cancer.The biological and clinical significance of MLL abnormalities in haematological malignancies.The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cellsMolecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents.Mediation of Af4 protein function in the cerebellum by Siah proteinsEpigenetics and blood disorders.Breakpoints of t(4;11) translocations in the human MLL and AF4 genes in ALL patients are preferentially clustered outside of high-affinity matrix attachment regions.The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.DDX6 transfers P-TEFb kinase to the AF4/AF4N (AFF1) super elongation complex.AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functionsTBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription.A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells.Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL.Localization of the fragile X mental retardation 2 (FMR2) protein in mammalian brain.Unique Familial MLL(KMT2A)-Rearranged Precursor B-Cell Infant Acute Lymphoblastic Leukemia in Non-twin Siblings.Genomic analysis of a four-way t(4;11;22;10) associated with MLL-AF4 in an adult acute lymphoblastic leukemia.The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.
P2860
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P2860
Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Exon/intron structure of the h ...... alterations in acute leukaemia
@ast
Exon/intron structure of the h ...... alterations in acute leukaemia
@en
Exon/intron structure of the h ...... alterations in acute leukaemia
@nl
type
label
Exon/intron structure of the h ...... alterations in acute leukaemia
@ast
Exon/intron structure of the h ...... alterations in acute leukaemia
@en
Exon/intron structure of the h ...... alterations in acute leukaemia
@nl
prefLabel
Exon/intron structure of the h ...... alterations in acute leukaemia
@ast
Exon/intron structure of the h ...... alterations in acute leukaemia
@en
Exon/intron structure of the h ...... alterations in acute leukaemia
@nl
P2093
P1476
Exon/intron structure of the h ...... alterations in acute leukaemia
@en
P2093
R Marschalek
P304
P356
10.1046/J.1365-2141.1997.1522966.X
P407
P577
1997-07-01T00:00:00Z