Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

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http://www.wikidata.org/entity/Q33933823

Q33933823

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The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6.Molecular mechanisms of etoposide Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanism TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo Gene rearrangements induced by the DNA double-strand cleaving agent neocarzinostatin: conservative non-homologous reciprocal exchanges in an otherwise stable genome.MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisom Heterogeneous duplications in patients with Pelizaeus-Merzbacher disease suggest a mechanism of coupled homologous and nonhomologous recombination.Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides Double-strand break repair by interchromosomal recombination: an in vivo repair mechanism utilized by multiple somatic tissues in mammals.Origins of chromosome translocations in childhood leukaemia.Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.Molecular pathogenesis of secondary acute promyelocytic leukemia Precursor B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: is it therapy-related?Secondary leukemia associated with the anti-cancer agent, etoposide, a topoisomerase II inhibitor Towards targeted therapy for infant acute lymphoblastic leukaemia.Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome Iron chelators with topoisomerase-inhibitory activity and their anticancer applications.Acute leukemia in early childhood.DNA topoisomerase II, genotoxicity, and cancer p53 chromatin epigenetic domain organization and p53 transcription.Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.Topoisomerase II and leukemia.Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci.Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements.A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E.Effects of topoisomerase 2 inhibitors on the MLL gene in children receiving chemotherapy: a prospective study.Role of Protein Linked DNA Breaks in Cancer.

P2860

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P2860

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

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http://www.wikidata.org/entity/Q33933823

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2001 nî lūn-bûn

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2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2001年の論文

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2001年論文

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2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

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2001年论文

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