Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia
about
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemiaAll trans retinoic acid in acute promyelocytic leukemia.Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O 3) in acute promyelocytic leukemia.Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factorComponents of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient.Human endogenous retrovirus protein cORF supports cell transformation and associates with the promyelocytic leukemia zinc finger protein.Comprehensive analysis of NuMA variation in breast cancer.Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYCExtramedullary disease in acute promyelocytic leukemia.The pathogenesis of acute promyelocytic leukaemia: evaluation of the role of molecular diagnosis and monitoring in the management of the disease.Acute promyelocytic leukemia: from treatment to genetics and back.In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications.Association of the NuMA region on chromosome 11q13 with breast cancer susceptibility.Retinoids in chemoprevention and differentiation therapy.Transcription therapy for acute promyelocytic leukaemia.Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.Characterization of genetic rearrangements in esophageal squamous carcinoma cell lines by a combination of M-FISH and array-CGH: further confirmation of some split genomic regions in primary tumors.Common themes in the pathogenesis of acute myeloid leukemia.In vivo analysis of the molecular genetics of acute promyelocytic leukemia.Translocations of the RARalpha gene in acute promyelocytic leukemia.The theory of APL.Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical and basic studies.Genetic profile of acute myeloid leukemia.Retinoid target genes in acute promyelocytic leukemia.Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell.Development of real-time quantitative polymerase chain reaction assays to track treatment response in retinoid resistant acute promyelocytic leukemia.Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1.RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.Mitotic spindle (DIS)orientation and DISease: cause or consequence?The C terminus of the nuclear protein NuMA: phylogenetic distribution and structure.Molecular Monitoring as a Path to Cure Acute Promyelocytic LeukemiaComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia.Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalphaReduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha.Impact of arsenic trioxide in the treatment of acute promyelocytic leukemia.The pathogenesis and management of the coagulopathy of acute promyelocytic leukaemia.Current treatment strategy of acute promyelocytic leukemia.Retinoid receptor signaling and autophagy in acute promyelocytic leukemia.RARA fusion genes in acute promyelocytic leukemia: a review.
P2860
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P2860
Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia
description
1997 nî lūn-bûn
@nan
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@ast
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@en
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@nl
type
label
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@ast
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@en
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@nl
prefLabel
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@ast
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@en
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@nl
P2860
P3181
P356
P1433
P1476
Fusion of retinoic acid recept ...... acute promyelocytic leukaemia
@en
P2093
C Catzavelos
P2860
P2888
P304
P3181
P356
10.1038/NG0997-109
P407
P577
1997-09-01T00:00:00Z