Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression - Wikidata - awgldk - TriplyDB

Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression

Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression

http://www.wikidata.org/entity/Q28253233

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Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)Contribution of amygdala pathology to comorbid emotional disturbances in temporal lobe epilepsy.Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders.Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders.Development of allosteric modulators of GPCRs for treatment of CNS disorders Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse.Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation Group II mGluRs modulate baseline and arthritis pain-related synaptic transmission in the rat medial prefrontal cortex.Novel Glutamatergic Treatments for Severe Mood Disorders.Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.The Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related Disorders Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors Therapeutic Modulation of Glutamate Receptors in Major Depressive Disorder Leading compounds for the validation of animal models of psychopathology.Novel glutamatergic drugs for the treatment of mood disorders.Glutamate-Based Drug Discovery for Novel Antidepressants.Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.Sex differences in glutamate receptor gene expression in major depression and suicide.Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2.The frontal cortex as a network hub controlling mood and cognition: Probing its neurochemical substrates for improved therapy of psychiatric and neurological disorders.PTSD-Related Behavioral Traits in a Rat Model of Blast-Induced mTBI Are Reversed by the mGluR2/3 Receptor Antagonist BCI-838.Beyond Ketamine: New Approaches to the Development of Safer Antidepressants.Differential Pharmacology and Binding of mGlu2 Receptor Allosteric Modulators.

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Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression

http://www.wikidata.org/entity/Q28253233

description

2011 nî lūn-bûn

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2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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Characterization of an mGluR2/ ...... in rodent models of depression

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Characterization of an mGluR2/ ...... in rodent models of depression

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Characterization of an mGluR2/ ...... in rodent models of depression

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Characterization of an mGluR2/ ...... in rodent models of depression

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Characterization of an mGluR2/ ...... in rodent models of depression

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Characterization of an mGluR2/ ...... in rodent models of depression

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01677063.2011.627485

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Journal of Neurogenetics

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Characterization of an mGluR2/ ...... in rodent models of depression

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Abdelhak Bessif

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Brice Campo

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Coline Legrand

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Delphine Parron

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Emmanuel Le Poul

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Francoise Girard

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Isabelle Royer-Urios

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Jean-Marie Vaugeois

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M El Yacoubi

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Manfred Schneider

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P2860

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.

Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agon

[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells

Regulation of neurotransmitter release by metabotropic glutamate receptors

Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes

Neurobiology of depression

Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.

Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons.

Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7

Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression.

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10.3109/01677063.2011.627485

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