Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
about
Alternative modes of binding of proteins with tandem SH2 domainsInteraction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signalingPhospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for SykMechanism of activation for Zap-70 catalytic activityThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationPositive and negative regulation of T-cell activation through kinases and phosphatasesThe gene for severe combined immunodeficiency disease in Athabascan-speaking Native Americans is located on chromosome 10p.Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membraneDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionBinding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteinsSyk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complexThe molecular pathology of primary immunodeficienciesThymus, innate immunity and autoimmune arthritis: interplay of gene and environmentStructural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase LinkerA novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory moleculesRegulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zetaSpecific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphataseTyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activationPhosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor functionSpecific immunoglobulin E responses in ZAP-70-deficient patients are mediated by Syk-dependent T-cell receptor signallingDifferential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinasesAssociation of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytesRhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte developmentp120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinaseFunctional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicityT cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins.The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.Autoimmunity in primary T-cell immunodeficiencies.Structural characterization of protein kinase A as a function of nucleotide binding. Hydrogen-deuterium exchange studies using matrix-assisted laser desorption ionization-time of flight mass spectrometry detection.Long-Term Outcomes of Hematopoietic Stem Cell Transplantation for ZAP70 Deficiency.Novel Combined Immune Deficiency and Radiation Sensitivity Blended Phenotype in an Adult with Biallelic Variations in ZAP70 and RNF168.Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.A general strategy for producing conditional alleles of Src-like tyrosine kinases.Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.Turning on natural killer cells.Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes.A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.
P2860
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P2860
Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@ast
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@en
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@nl
type
label
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@ast
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@en
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@nl
prefLabel
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@ast
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@en
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@nl
P2093
P3181
P356
P1433
P1476
Human severe combined immunode ...... P-70, a T cell tyrosine kinase
@en
P2093
T G Parslow
P304
P3181
P356
10.1126/SCIENCE.8202712
P407
P577
1994-06-10T00:00:00Z