The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1 - Wikidata - awgldk - TriplyDB

The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1

The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1

http://www.wikidata.org/entity/Q28254964

about

The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK Identification of HEXIM1 as a positive regulator of p53 FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice HEXIM1 induces differentiation of human pluripotent stem cells The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2 Cellular mRNA activates transcription elongation by displacing 7SK RNA.Determination of hexamethylene bisacetamide, an antineoplastic compound, in mouse and human plasma by LC-MS/MS Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism Modulatory effects of alpha- and gamma-tocopherols on 4-hydroxyestradiol induced oxidative stresses in MCF-10A breast epithelial cells.HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb Defining mechanisms that regulate RNA polymerase II transcription in vivo HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland.Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor.The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors.The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation HEXIM1 is a critical determinant of the response to tamoxifen.Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells.HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability.Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters.Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells.Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ERα-positive breast tumorigenesis.PKC phosphorylates HEXIM1 and regulates P-TEFb activity.Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis.Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription Cyclins, cyclin dependent kinases, and regulation of steroid receptor action.Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis.Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes HEXIM1, a New Player in the p53 Pathway

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The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1

http://www.wikidata.org/entity/Q28254964

description

2005 nî lūn-bûn

@nan

2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

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2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

The breast cell growth inhibit ...... al elongation factor cyclin T1

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The breast cell growth inhibit ...... al elongation factor cyclin T1

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The breast cell growth inhibit ...... al elongation factor cyclin T1

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type

label

The breast cell growth inhibit ...... al elongation factor cyclin T1

@ast

The breast cell growth inhibit ...... al elongation factor cyclin T1

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The breast cell growth inhibit ...... al elongation factor cyclin T1

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The breast cell growth inhibit ...... al elongation factor cyclin T1

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Bryan M Wittmann

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Huayun Deng

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Koh Fujinaga

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Monica M Montano

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P2860

An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens

Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter

MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner

A system for stable expression of short interfering RNAs in mammalian cells

Connections and regulation of the human estrogen receptor

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation

Structure, expression, and functional characterization of the mouse CLP-1 gene

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scholarly article

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1664054

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10.1038/SJ.ONC.1208728

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36

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24

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1003111053

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15940264

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