Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism - Wikidata - awgldk - TriplyDB

Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism

Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism

http://www.wikidata.org/entity/Q33432584

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HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen.Anti-Cancer Drug HMBA Acts as an Adjuvant during Intracellular Bacterial Infections by Inducing Type I IFN through STING.Hexim1, an RNA-controlled protein hub.

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P2860

Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism

http://www.wikidata.org/entity/Q33432584

description

2016 nî lūn-bûn

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2016 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2016 թվականի մայիսին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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name

Induction of HEXIM1 activities ...... nal consequences and mechanism

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Induction of HEXIM1 activities ...... nal consequences and mechanism

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type

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Induction of HEXIM1 activities ...... nal consequences and mechanism

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Induction of HEXIM1 activities ...... nal consequences and mechanism

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Induction of HEXIM1 activities ...... nal consequences and mechanism

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Induction of HEXIM1 activities ...... nal consequences and mechanism

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J.CANLET.2016.05.029

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Induction of HEXIM1 activities ...... nal consequences and mechanism

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Bin Su

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Haoyan Zhou

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I-Ju Yeh

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Justin Lathia

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Monica M Montano

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Ofer Reizes

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Praveena S Thiagarajan

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Wannarasmi Ketchart

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P2860

Identification of HEXIM1 as a positive regulator of p53

Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA

HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b

Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors

The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1

P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent.

Phase I trial using adaptive control dosing of hexamethylene bisacetamide (NSC 95580).

Phase I trial and clinical pharmacological evaluation of hexamethylene bisacetamide administration by ten-day continuous intravenous infusion at twenty-eight-day intervals.

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60-69

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10.1016/J.CANLET.2016.05.029

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