Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex
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Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bondNerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VIMutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand diseaseLateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathwayIncreased thrombin responsiveness in platelets from mice lacking glycoprotein VMeasurement of the binding forces between von Willebrand factor and variants of platelet glycoprotein Ibalpha using optical tweezers.Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta).O-linked carbohydrate of recombinant von Willebrand factor influences ristocetin-induced binding to platelet glycoprotein 1b.Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo.Primary structure of two-chain botrocetin, a von Willebrand factor modulator purified from the venom of Bothrops jararacaAnalysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression modelThe role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activationA functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complexSrc family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis.von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function.Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage.The Interaction of von Willebrand Factor and the Platelet Glycoprotein Ib-IX Complex.Effects of different amino-acid substitutions in the leucine 694-proline 708 segment of recombinant von Willebrand factor.The cytoplasmic domain of the alpha-subunit of glycoprotein (GP) Ib mediates attachment of the entire GP Ib-IX complex to the cytoskeleton and regulates von Willebrand factor-induced changes in cell morphology.The collagen-binding integrin α2β1 is a novel interaction partner of the Trimeresurus flavoviridis venom protein flavocetin-A.A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI.Tyrosine sulfation of glycoprotein I(b)alpha. Role of electrostatic interactions in von Willebrand factor binding.Identification of amino acid residues essential for von Willebrand factor binding to platelet glycoprotein Ib. Charged-to-alanine scanning mutagenesis of the A1 domain of human von Willebrand factor.Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ibalpha under flow.Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ibalpha.Neutrophil proteinase cathepsin G is proteolytically active on the human platelet glycoprotein Ib-IX receptor: characterization of the cleavage sites within the glycoprotein Ib alpha subunit.Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner.Reconstitution of the platelet glycoprotein Ib-IX complex in phospholipid bilayer Nanodiscs.Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal.The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation.Identification of the amino acid residues of the platelet glycoprotein Ib (GPIb) essential for the von Willebrand factor binding by clustered charged-to-alanine scanning mutagenesis.Binding of von Willebrand factor to the small proteoglycan decorin.A template-assembled synthetic protein surface mimetic of the von Willebrand factor A1 domain inhibits botrocetin-induced platelet aggregation.Inhibition of Binding of von Willebrand Factor to the Platelet Glycoprotein Ib-IX Complex, Heparin and Sulfatides by Polyanionic Compounds. The Mechanism of Modulation of the Adhesive Function of von Willebrand Factor.Extracellular signal-regulated kinase 5 associates with casein kinase II to regulate GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway.
P2860
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P2860
Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex
description
1989 nî lūn-bûn
@nan
1989 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@ast
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@en
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@nl
type
label
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@ast
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@en
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@nl
prefLabel
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@ast
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@en
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@nl
P2093
P3181
P356
P1433
P1476
Purification of botrocetin fro ...... ane glycoprotein Ib-IX complex
@en
P2093
J J Gorman
M C Berndt
P A Castaldi
R K Andrews
P304
P3181
P356
10.1021/BI00447A009
P407
P577
1989-10-17T00:00:00Z