The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation
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An important role of the SRC family kinase Lyn in stimulating platelet granule secretionHeat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality.Antiplatelet Activity of a Newly Synthesized Novel Ruthenium (II): A Potential Role for Akt/JNK SignalingSyk Activity Is Dispensable for Platelet GP1b-IX-V Signaling.Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.A G(i) -independent mechanism mediating Akt phosphorylation in platelets.The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregationSignaling during platelet adhesion and activationLipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles.Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling.G protein-dependent basal and evoked endothelial cell vWF secretion.Suppressive effect of CORM-2 on LPS-induced platelet activation by glycoprotein mediated HS1 phosphorylation interferenceEchicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregationBiphasic roles for soluble guanylyl cyclase (sGC) in platelet activation.An important role for Akt3 in platelet activation and thrombosisRole for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregationAmbient fine particles (PM2.5 ) attenuate collagen-induced platelet activation through interference of the PLCγ2/Akt/GSK3β signaling pathway.A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complexSrc family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin.Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticlesLIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis.Inducing mitophagy in diabetic platelets protects against severe oxidative stress.Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathwayInduction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae.ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease.Interference with akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress.Akt signaling in platelets and thrombosis.Novel roles of cAMP/cGMP-dependent signaling in platelets.The serum- & glucocorticoid-inducible kinase in the regulation of platelet function.Of von Willebrand factor and platelets.New Concepts and Mechanisms of Platelet Activation Signaling.The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow.The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation.ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.Modularity of the oncoprotein-like properties of platelet glycoprotein Ibalpha.GPIbalpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation events.Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of phosphoinositide 3-kinase.Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets.
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P2860
The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
The role of Akt in the signali ...... IX induced platelet activation
@ast
The role of Akt in the signali ...... IX induced platelet activation
@en
type
label
The role of Akt in the signali ...... IX induced platelet activation
@ast
The role of Akt in the signali ...... IX induced platelet activation
@en
prefLabel
The role of Akt in the signali ...... IX induced platelet activation
@ast
The role of Akt in the signali ...... IX induced platelet activation
@en
P2093
P2860
P1433
P1476
The role of Akt in the signali ...... IX induced platelet activation
@en
P2093
Aleksandra Stojanovic
Nissim Hay
Xiaoping Du
P2860
P304
P356
10.1182/BLOOD-2007-04-085514
P407
P577
2007-10-03T00:00:00Z