Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary - Wikidata - awgldk - TriplyDB

Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary

Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary

http://www.wikidata.org/entity/Q28259645

about

Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas Ack1 tyrosine kinase activation correlates with pancreatic cancer progression Germline PTEN mutations in Cowden syndrome-like families.The genetics of transitional cell carcinoma: progress and potential clinical application.Expression of the DMBT1 gene is frequently suppressed in human lung cancer.Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells PTEN loss accelerates KrasG12D-induced pancreatic cancer development Polymorphisms in PTEN in breast cancer families.ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas.Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma Genetic deletion and pharmacological inhibition of Akt1 isoform attenuates bladder cancer cell proliferation, motility and invasion.Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas.Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1.Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas.TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells.Integrative survival-based molecular profiling of human pancreatic cancer.Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma.Metabolism addiction in pancreatic cancer.Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas.The challenge of pancreatic cancer therapy and novel treatment strategy using engineered mesenchymal stem cells.PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells.TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic cancer cells.Akt activation in renal cell carcinoma: contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor.In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic cancer.Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles.Loss of tumor suppressor protein PTEN during renal carcinogenesis.Frequent nuclear accumulation of beta-catenin in pituitary adenoma.Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer.Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1.The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia.

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Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary

http://www.wikidata.org/entity/Q28259645

description

1997 nî lūn-bûn

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1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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1997年の論文

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Japanese Journal of Cancer Research

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DNA sequencing with chain-terminating inhibitors

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

Dideoxy sequencing method using denatured plasmid templates

A tiger behind many doors: multiple genetic pathways to malignant glioma.

Epidemiological study of primary intracranial tumors: a regional survey in Kumamoto Prefecture in the southern part of Japan.

Epidemiology of brain tumors: the national survey of intracranial neoplasms.

Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

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