Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion
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Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane rufflesNegative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1Association of Grb7 with phosphoinositides and its role in the regulation of cell migrationRegulation of focal adhesion kinase by a novel protein inhibitor FIP200Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathwaysSuppression of Pyk2 kinase and cellular activities by FIP200LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.In-situ coupling between kinase activities and protein dynamics within single focal adhesions.Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase.NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding modelPyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.Pyk2/CAKbeta tyrosine kinase activity-mediated angiogenesis of pulmonary vascular endothelial cellsDecreased cell adhesion promotes angiogenesis in a Pyk2-dependent mannerConditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesisFocal adhesion kinase: in command and control of cell motilityPaxillin: a focal adhesion-associated adaptor protein.Involvement of proline-rich tyrosine kinase 2 in platelet activation: tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2.Interactions of the protein-tyrosine phosphatase-α with the focal adhesion targeting domain of focal adhesion kinase are involved in interleukin-1 signaling in fibroblasts.Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathwayTargeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cellsPaxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinaseSuppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator.Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression.Integrin beta8 (ITGB8) activates VAV-RAC1 signaling via FAK in the acquisition of endometrial epithelial cell receptivity for blastocyst implantation.Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.Outside-in signaling pathway linked to CD146 engagement in human endothelial cells.Focal adhesion kinase is involved in mechanosensing during fibroblast migration.Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells.Targeting Pyk2 for therapeutic interventionThe Pyk2 FERM regulates Pyk2 complex formation and phosphorylationCompensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.Differential expression of FAK and Pyk2 in metastatic and non-metastatic EL4 lymphoma cell linesDFak56 is a novel Drosophila melanogaster focal adhesion kinaseExpression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivoCharacterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependenceFocal adhesion kinase-related proline-rich tyrosine kinase 2 and focal adhesion kinase are co-overexpressed in early-stage and invasive ErbB-2-positive breast cancer and cooperate for breast cancer cell tumorigenesis and invasiveness.Analysis of the calcium-dependent regulation of proline-rich tyrosine kinase 2 by gonadotropin-releasing hormoneLPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway.LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2
P2860
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P2860
Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Differential regulation of Pyk ...... fers response to cell adhesion
@ast
Differential regulation of Pyk ...... fers response to cell adhesion
@en
Differential regulation of Pyk ...... fers response to cell adhesion
@nl
type
label
Differential regulation of Pyk ...... fers response to cell adhesion
@ast
Differential regulation of Pyk ...... fers response to cell adhesion
@en
Differential regulation of Pyk ...... fers response to cell adhesion
@nl
prefLabel
Differential regulation of Pyk ...... fers response to cell adhesion
@ast
Differential regulation of Pyk ...... fers response to cell adhesion
@en
Differential regulation of Pyk ...... fers response to cell adhesion
@nl
P2093
P3181
P356
P1476
Differential regulation of Pyk ...... fers response to cell adhesion
@en
P2093
P304
P3181
P356
10.1074/JBC.273.4.2384
P407
P577
1998-01-23T00:00:00Z