Structure, dynamics, and catalytic function of dihydrofolate reductase
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A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysisExpanding the concepts in protein structure-function relationships and enzyme kinetics: Teaching using morpheeinsThermodynamic analysis shows conformational coupling and dynamics confer substrate specificity in fructose-1,6-bisphosphate aldolaseLong noncoding RNAs: past, present, and futureComplex structure of Bacillus subtilis RibG: the reduction mechanism during riboflavin biosynthesisIncreased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activityThe Solution Structure of Bacillus anthracis Dihydrofolate Reductase Yields Insight into the Analysis of Structure−Activity Relationships for Novel InhibitorsA Correspondence Between Solution-State Dynamics of an Individual Protein and the Sequence and Conformational Diversity of its FamilyComparison of NMR and crystal structures highlights conformational isomerism in protein active sitesDivergent evolution of protein conformational dynamics in dihydrofolate reductase.Keep on moving: discovering and perturbing the conformational dynamics of enzymesThe importance of ensemble averaging in enzyme kineticsMolecular dynamics and protein function.At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductaseEvolution-Based Functional Decomposition of ProteinsHot spots for allosteric regulation on protein surfacesPerspective: Defining and quantifying the role of dynamics in enzyme catalysisIntrinsic dynamics of an enzyme underlies catalysisEffects of Non-Natural Amino Acid Incorporation into the Enzyme Core Region on Enzyme Structure and Function.Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography.Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification.Conformational analysis of a nitroxide side chain in an α-helix with density functional theory.Direct observation of fast protein conformational switchingIntegrating protein structural dynamics and evolutionary analysis with Bio3D.Protein dynamics and stability: the distribution of atomic fluctuations in thermophilic and mesophilic dihydrofolate reductase derived using elastic incoherent neutron scattering.Active-site motions and polarity enhance catalytic turnover of hydrated subtilisin dissolved in organic solvents.Pharmacophore-based virtual screening versus docking-based virtual screening: a benchmark comparison against eight targets.2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands.Molecular Characteristics and Serodiagnostic Potential of Dihydrofolate Reductase from Echinococcus granulosus.Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.Experimental validation of FINDSITE(comb) virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders.A surprising role for conformational entropy in protein function.An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling.Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis.Structure and dynamics of a processive Brownian motor: the translating ribosomeA general chemical method to regulate protein stability in the mammalian central nervous systemLigand binding modulates the mechanical stability of dihydrofolate reductase.
P2860
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P2860
Structure, dynamics, and catalytic function of dihydrofolate reductase
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Structure, dynamics, and catalytic function of dihydrofolate reductase
@ast
Structure, dynamics, and catalytic function of dihydrofolate reductase
@en
Structure, dynamics, and catalytic function of dihydrofolate reductase
@nl
type
label
Structure, dynamics, and catalytic function of dihydrofolate reductase
@ast
Structure, dynamics, and catalytic function of dihydrofolate reductase
@en
Structure, dynamics, and catalytic function of dihydrofolate reductase
@nl
altLabel
Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase
@en
prefLabel
Structure, dynamics, and catalytic function of dihydrofolate reductase
@ast
Structure, dynamics, and catalytic function of dihydrofolate reductase
@en
Structure, dynamics, and catalytic function of dihydrofolate reductase
@nl
P2093
P3181
P1476
Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase
@en
Structure, dynamics, and catalytic function of dihydrofolate reductase
@en
P2093
H Jane Dyson
Jason R Schnell
Jason R. Schnell
P3181
P356
10.1146/ANNUREV.BIOPHYS.33.110502.133613
P407
P577
2004-06-09T00:00:00Z