Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
about
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic diseaseGrowth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesityMir-34a is upregulated during liver regeneration in rats and is associated with the suppression of hepatocyte proliferation.Differential gene expression between neuropeptide Y expressing neurons of the dorsomedial nucleus of the hypothalamus and the arcuate nucleus: microarray analysis study.Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesityInhibin at 90: from discovery to clinical application, a historical reviewActivins and follistatins: Emerging roles in liver physiology and cancerActivin B antagonizes RhoA signaling to stimulate mesenchymal morphology and invasiveness of clear cell renal cell carcinomas.Alk7 Depleted Mice Exhibit Prolonged Cardiac Repolarization and Are Predisposed to Ventricular Arrhythmia.Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditureNodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells.Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivityActivin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signalingActivinB Is Induced in Insulinoma To Promote Tumor Plasticity through a β-Cell-Induced DedifferentiationTransforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell functionThe biology of activin: recent advances in structure, regulation and functionActivin signaling: effects on body composition and mitochondrial energy metabolismSystemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster.ALK7 gene polymorphism is associated with metabolic syndrome risk and cardiovascular remodelingAntagonism of activin by activin chimeras.Genome-wide identification of palmitate-regulated immediate early genes and target genes in pancreatic beta-cells reveals a central role of NF-κB.Activins and Inhibins: Roles in Development, Physiology, and Disease.Regulation of the Iron Homeostatic Hormone Hepcidin.TGF-β Family Signaling in Drosophila.ALK7 protects against pathological cardiac hypertrophy in mice.Roles of activin receptor-like kinase 7 signaling and its target, peroxisome proliferator-activated receptor γ, in lean and obese adipocytes.Emerging roles for the TGFbeta family in pancreatic beta-cell homeostasis.Silencing of activin receptor-like kinase 7 alleviates aortic stiffness in type 2 diabetic rats.Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor γ and C/EBPα.A novel crosstalk between Alk7 and cGMP signaling differentially regulates brown adipocyte functionGeneration of a conditional mouse model to target Acvr1b disruption in adult tissues.Expression of activin receptor-like kinase 7 in adipose tissues.Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands.SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity.
P2860
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P2860
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
description
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2008
@ast
im Mai 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/05/20)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/05/20)
@nl
наукова стаття, опублікована в травні 2008
@uk
name
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@ast
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@en
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@nl
type
label
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@ast
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@en
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@nl
prefLabel
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@ast
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@en
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@nl
P2093
P2860
P356
P1476
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function
@en
P2093
Carlos F. Ibáñez
Eva Reissmann
Olov Andersson
Philippe Bertolino
Rebecka Holmberg
P2860
P304
P356
10.1073/PNAS.0801285105
P407
P577
2008-05-20T00:00:00Z