Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter
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Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistryVesicular monoamine transporter 2: role as a novel target for drug developmentDes-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transportersComputational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine releaseLobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.(2S,6S)-1-Methyl-2,6-trans-distyryl-piperidinium chloride.1-Methyl-2,6-cis-distyrylpiperidine.Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving ratsSynthesis of symmetrical 1,5-disubstituted granatanines.Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).Preclinical Efficacy of Novel Vesicular Monoamine Transporter 2 Inhibitors as Antagonists of d-Methamphetamine Self-Administration in Rats.Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration.Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivoImportance of Substrate-Coupled Proton Antiport by the Vesicular Monoamine Transporter in the Actions of Amphetamines in Drosophila Brain.Synthesis of Lobeline, Lobelane and their Analogues. A Review.Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues.Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.(E,E)-1-Methyl-2,6-distyrylpyridinium iodide.Efficient synthesis of cis-2,6-di-(2- quinolylpiperidine).Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake.Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.cis-2,5-Bis(2-fluoro-5-meth-oxy-pheneth-yl)pyrrolidinium formate.Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.cis-1-Benzyl-pyrrolidine-2,5-dicarbonitrile.Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: applications to the total synthesis of alkaloids.3-[(Aryl)(4-fluorobenzyloxy)methyl]piperidine derivatives: high-affinity ligands for the serotonin transporter.Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2.Iterative direct C(sp3)-H functionalization of amines: diastereoselective divergent syntheses of α,α'-disubstituted alicyclic amines.Solvent-free double aza-Michael under ultrasound irradiation: diastereoselective sequential one-pot synthesis of pyrrolidine Lobelia alkaloids analogues.
P2860
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P2860
Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Defunctionalized lobeline anal ...... esicular monoamine transporter
@ast
Defunctionalized lobeline anal ...... esicular monoamine transporter
@en
Defunctionalized lobeline anal ...... esicular monoamine transporter
@nl
type
label
Defunctionalized lobeline anal ...... esicular monoamine transporter
@ast
Defunctionalized lobeline anal ...... esicular monoamine transporter
@en
Defunctionalized lobeline anal ...... esicular monoamine transporter
@nl
prefLabel
Defunctionalized lobeline anal ...... esicular monoamine transporter
@ast
Defunctionalized lobeline anal ...... esicular monoamine transporter
@en
Defunctionalized lobeline anal ...... esicular monoamine transporter
@nl
P2093
P2860
P356
P1476
Defunctionalized lobeline anal ...... esicular monoamine transporter
@en
P2093
Agripina G Deaciuc
Guangrong Zheng
Linda P Dwoskin
Peter A Crooks
Seth D Norrholm
P2860
P304
P356
10.1021/JM0501228
P407
P577
2005-08-25T00:00:00Z