Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter - Wikidata - awgldk - TriplyDB

Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter

Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter

http://www.wikidata.org/entity/Q28267727

about

Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistry Vesicular monoamine transporter 2: role as a novel target for drug development Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2 meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.(2S,6S)-1-Methyl-2,6-trans-distyryl-piperidinium chloride.1-Methyl-2,6-cis-distyrylpiperidine.Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2 Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving rats Synthesis of symmetrical 1,5-disubstituted granatanines.Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2 Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).Preclinical Efficacy of Novel Vesicular Monoamine Transporter 2 Inhibitors as Antagonists of d-Methamphetamine Self-Administration in Rats.Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration.Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo Importance of Substrate-Coupled Proton Antiport by the Vesicular Monoamine Transporter in the Actions of Amphetamines in Drosophila Brain.Synthesis of Lobeline, Lobelane and their Analogues. A Review.Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues.Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.(E,E)-1-Methyl-2,6-distyrylpyridinium iodide.Efficient synthesis of cis-2,6-di-(2- quinolylpiperidine).Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake.Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.cis-2,5-Bis(2-fluoro-5-meth-oxy-pheneth-yl)pyrrolidinium formate.Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.cis-1-Benzyl-pyrrolidine-2,5-dicarbonitrile.Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: applications to the total synthesis of alkaloids.3-[(Aryl)(4-fluorobenzyloxy)methyl]piperidine derivatives: high-affinity ligands for the serotonin transporter.Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2.Iterative direct C(sp3)-H functionalization of amines: diastereoselective divergent syntheses of α,α'-disubstituted alicyclic amines.Solvent-free double aza-Michael under ultrasound irradiation: diastereoselective sequential one-pot synthesis of pyrrolidine Lobelia alkaloids analogues.

P2860

Q24601233-AB3092A4-797F-40AC-A43A-529EDB8C83CE Q24647764-4A996CF3-41AA-418C-909F-20D342454001 Q28257395-6C398F39-3EE9-4B0A-8161-697D3CC42D27 Q28290902-7C70BA0B-0ED2-4DCF-B360-E06C7C7C6A8F Q30498938-015DD32E-8330-4129-90F9-A623B7E92FB2 Q33613631-1EAEC7F0-37A9-4FFC-850F-ED7247BBA1D4 Q33738102-E24DE93A-6696-488F-8E82-AB144E29582B Q33854736-F2EFB5A1-8BFC-490E-A011-CA42702BED1A Q34202539-2E2D32F8-B8A8-43F8-8FC4-79A60FC89E3D Q34304160-5F6D94E7-7649-4BDB-8029-5B47A993B3FB Q34304546-94CF4D6A-6147-497F-A215-93D2D74166D3 Q34702317-92CF85E5-5125-4ACD-8B82-CCC9CB76A637 Q35801356-C08D5B19-9E48-4A52-8B5D-A0AC96888722 Q36840309-E05D36D0-B4EE-4948-B775-E6D7B5EDD734 Q37052436-09F536FF-D5FC-4B52-A435-C8AEAF31D6DB Q37052442-6F58D68D-C2A4-4E17-AE3C-BA63EDAB5A2E Q37052450-0DBA3A85-E396-4008-AD56-D55811F3429B Q37068964-F5C3DC06-A583-4A69-B30A-255882476ADB Q37190441-DB9D1A1F-E2E0-443B-B2E2-0102CD6AB624 Q37227997-10AAC4C4-36CA-4CE9-83F6-95B32FB881BE Q37619367-FE2F89F0-DBD6-46DC-ACCC-74F1C689D71C Q38267226-1BA542DB-7C7B-42A8-87D7-5A168C41F039 Q38274875-70208A8B-49F3-41A4-83FE-FE2484571FC6 Q40664282-E15F4247-5F52-4ABD-926B-417995480E36 Q41350651-885088B1-7E2D-4329-B1C3-F2A1DF28C09C Q41916634-6179352C-489F-4E00-9BC3-1283ECF3F1BB Q41916645-9EB9D4DF-329A-4552-B77A-1631CF81F3BE Q42098885-8174FADF-28DA-4149-9FEC-37A76251832D Q42141981-8AAF9853-54E9-46BE-999C-B5B228E057F4 Q42373565-F917F978-97FC-462C-A09C-A7081EF1FA91 Q42682103-20E60BE2-ACC6-456C-9D32-2092485B268F Q42737678-508C36C2-B43D-470B-B38A-292A1A4147F0 Q43070321-B17FE5DF-9F1D-4AA4-B846-391E463253DF Q43249638-CAA24B34-910F-4FEC-8E51-EC2DEBE10801 Q46970780-3ACE6568-6F75-4CB3-AC61-31B6A6067CAB Q47387524-BE13EBE7-6915-4813-B229-9DB635D87EA4 Q48855535-A44A9235-4D48-44B7-9FAA-36A92110CA6F Q54234695-80AC3F2A-F6B7-4FD7-B751-197B040A5D98

P2860

Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter

http://www.wikidata.org/entity/Q28267727

description

2005 nî lūn-bûn

@nan

2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Defunctionalized lobeline anal ...... esicular monoamine transporter

@ast

Defunctionalized lobeline anal ...... esicular monoamine transporter

@en

Defunctionalized lobeline anal ...... esicular monoamine transporter

@nl

type

label

Defunctionalized lobeline anal ...... esicular monoamine transporter

@ast

Defunctionalized lobeline anal ...... esicular monoamine transporter

@en

Defunctionalized lobeline anal ...... esicular monoamine transporter

@nl

prefLabel

Defunctionalized lobeline anal ...... esicular monoamine transporter

@ast

Defunctionalized lobeline anal ...... esicular monoamine transporter

@en

Defunctionalized lobeline anal ...... esicular monoamine transporter

@nl

P1433

Q28267727-344659F8-7BF5-4833-83FB-3AD544AC8470

P1476

Q28267727-4E5A5234-7F0B-4C82-BE18-2C4803F79F45

P2093

Q28267727-48A64D7D-EA37-4255-B706-96E206D615D4

Q28267727-8C78A20E-8A91-4281-8023-93A6BF609EE1

Q28267727-93101615-88D1-4A87-AB90-29919F67F36C

Q28267727-9980727B-4AFA-4A29-A872-102B0538984B

Q28267727-C1B544B7-F305-41BD-9058-EE22166A04A7

P2860

Q28267727-013FA74C-2FFC-41D7-84E6-AE10158FF072

Q28267727-01F50893-EDE0-417F-906E-E306A4D32BA4

Q28267727-07B82A1A-A467-4A59-8377-0A88A5E4E6D7

Q28267727-095270BA-29AF-45CA-BF11-20C0D74AB215

Q28267727-25636DDA-208F-4DFB-8D5B-CC45EA544A70

Q28267727-5D45946B-3FDE-407B-ADF4-E6085B32CAA4

Q28267727-5EC0E8A6-6CB8-44EC-B601-BEAC2D630700

Q28267727-66DBD2F9-8DB3-485B-A98F-C0B6DFC411B3

Q28267727-70E5E534-B857-4006-B122-B4A8516FA7A2

Q28267727-7166F434-1979-4D09-9520-3D5E87BDE9BA

P304

Q28267727-183AAD90-9C88-449A-954C-1F0DBFF28668

P31

Q28267727-07838420-B01A-4FE5-BBC6-8EDF836393E7

P356

Q28267727-452662C8-D5F4-4C61-9604-7513E38FD05B

P407

Q28267727-24BF963A-5E74-4F49-80AE-B36CD54E1CBD

P433

Q28267727-9706CB2E-08AB-478B-A258-24CB115106CC

P478

Q28267727-3E0C8666-F201-45D9-BE0F-118020341BE9

P577

Q28267727-650020AF-A4F9-4160-929E-8D2F28EC8FBF

P5875

Q28267727-46241734-E172-47A9-9665-C88C53A6ED53

P698

Q28267727-1E756899-2FC6-4B8D-BF62-014D30ADB6C1

P921

Q28267727-FAE2AF0D-E0DE-4E9B-8788-D1412F275208

P932

Q28267727-1C76454B-5052-4A68-AC3B-9B45658E8233

P356

P1433

Journal of Medicinal Chemistry

P1476

Defunctionalized lobeline anal ...... esicular monoamine transporter

@en

P2093

Agripina G Deaciuc

http://www.w3.org/2001/XMLSchema#string

Guangrong Zheng

http://www.w3.org/2001/XMLSchema#string

Linda P Dwoskin

http://www.w3.org/2001/XMLSchema#string

Peter A Crooks

http://www.w3.org/2001/XMLSchema#string

Seth D Norrholm

http://www.w3.org/2001/XMLSchema#string

P2860

Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

Regulation of the vesicular monoamine transporter-2: a novel mechanism for cocaine and other psychostimulants

Lobeline attenuates locomotor stimulation induced by repeated nicotine administration in rats

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

Lobeline inhibits the neurochemical and behavioral effects of amphetamine.

Cocaine self-administration in dopamine-transporter knockout mice.

Activation and inhibition of the human alpha7 nicotinic acetylcholine receptor by agonists.

A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse.

Impact of psychostimulants on vesicular monoamine transporter function.

P304

5551-60

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/JM0501228

http://www.w3.org/2001/XMLSchema#string

P407

P433

17

http://www.w3.org/2001/XMLSchema#string

P478

48

http://www.w3.org/2001/XMLSchema#string

P577

2005-08-25T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7653863

http://www.w3.org/2001/XMLSchema#string

P698

16107155

http://www.w3.org/2001/XMLSchema#string

P921

P932

3617589

http://www.w3.org/2001/XMLSchema#string