Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2. - Wikidata - awgldk - TriplyDB

Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.

Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.

http://www.wikidata.org/entity/Q33613631

about

VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.Preparation and Characterization of Tetrabenazine Enantiomers against Vesicular Monoamine Transporter 2.Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2 Pre-gestational stress alters stress-response of pubertal offspring rat in sexually dimorphic and hemispherically asymmetric manner.New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2)Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis.The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats.Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2 Celecoxib reduces brain dopaminergic neuronaldysfunction, and improves sensorimotor behavioral performance in neonatal rats exposed to systemic lipopolysaccharide.Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2 Preclinical Efficacy of Novel Vesicular Monoamine Transporter 2 Inhibitors as Antagonists of d-Methamphetamine Self-Administration in Rats.Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration.Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine Diet-induced obesity: dopamine transporter function, impulsivity and motivation.Importance of Substrate-Coupled Proton Antiport by the Vesicular Monoamine Transporter in the Actions of Amphetamines in Drosophila Brain.Synthesis of Lobeline, Lobelane and their Analogues. A Review.Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease.Argon blocks the expression of locomotor sensitization to amphetamine through antagonism at the vesicular monoamine transporter-2 and mu-opioid receptor in the nucleus accumbens.Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.Oral administration of GZ-793A, a VMAT2 inhibitor, decreases methamphetamine self-administration in rats.Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).

P2860

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P2860

Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.

http://www.wikidata.org/entity/Q33613631

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

@ja

2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

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2009年論文

@zh-tw

2009年论文

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name

Lobelane inhibits methamphetam ...... cular monoamine transporter-2.

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Lobelane inhibits methamphetam ...... cular monoamine transporter-2.

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type

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Lobelane inhibits methamphetam ...... cular monoamine transporter-2.

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Lobelane inhibits methamphetam ...... cular monoamine transporter-2.

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Lobelane inhibits methamphetam ...... cular monoamine transporter-2.

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Lobelane inhibits methamphetam ...... cular monoamine transporter-2.

@en

P2093

Gabriela Deaciuc

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Guangrong Zheng

http://www.w3.org/2001/XMLSchema#string

Justin R Nickell

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Kiran B Siripurapu

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Linda P Dwoskin

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Peter A Crooks

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Sairam Krishnamurthy

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Seth Norrholm

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P2860

Regulation of the vesicular monoamine transporter-2: a novel mechanism for cocaine and other psychostimulants

Brain reward circuitry: insights from unsensed incentives

Lobeline effects on tonic and methamphetamine-induced dopamine release

Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter

Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats

Lobeline inhibits the neurochemical and behavioral effects of amphetamine.

Activation and inhibition of the human alpha7 nicotinic acetylcholine receptor by agonists.

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