Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A
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Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptorMechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length constructBinding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activityCrystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMPSolution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGEThe Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational ChangeConformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF DomainStructures of the PelD Cyclic Diguanylate Effector Involved in Pellicle Formation in Pseudomonas aeruginosa PAO1cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac MyocytesPDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation.Cyclic AMP signalling pathways in the regulation of uterine relaxation.Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterasesCyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insightsCrystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerizationThe cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites.cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2.Regulation of cAMP by phosphodiesterases in erythrocytes.Phosphodiesterases and cyclic GMP regulation in heart muscle.Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain.Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5.cGMP-dependent protein kinase II and aldosterone secretion.Inhibitors of phosphodiesterases PDE2, PDE3, and PDE4 do not increase the sinoatrial tachycardia of noradrenaline and prostaglandin PGE₁ in mice.Molecular determinants of cGMP binding to chicken cone photoreceptor phosphodiesterase.Functional chimeras of the phosphodiesterase 5 and 10 tandem GAF domains.A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea.
P2860
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P2860
Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@ast
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@en
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@nl
type
label
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@ast
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@en
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@nl
prefLabel
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@ast
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@en
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@nl
P2093
P2860
P356
P1476
Molecular determinants for cyc ...... omains of phosphodiesterase 2A
@en
P2093
Albert Y Wu
Joseph A Beavo
Kaori Ikeda
Sergio E Martinez
Xiao-Bo Tang
P2860
P304
P356
10.1074/JBC.M404287200
P407
P577
2004-09-03T00:00:00Z