cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11 - Wikidata - awgldk - TriplyDB

cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11

cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11

http://www.wikidata.org/entity/Q28285255

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Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity Molecular details of cAMP generation in mammalian cells: a tale of two systems Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012 Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain Crystal structure of the GAF-B domain from human phosphodiesterase 5 Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [¹¹C]MP-10 PET rodent imaging study with ex vivo confirmation.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).Activation of PDE10 and PDE11 phosphodiesterases.Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway.Patented PDE10A inhibitors: novel compounds since 2007.Clinical and molecular genetics of the phosphodiesterases (PDEs).Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter.Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases.Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi.Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport.[18F]JNJ42259152 binding to phosphodiesterase 10A, a key regulator of medium spiny neuron excitability, is altered in the presence of cyclic AMP.Activation of PDE2 and PDE5 by specific GAF ligands: delayed activation of PDE5.Phosphodiesterase type 2 and the homeostasis of cyclic GMP in living thalamic neurons.Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels.Functional chimeras of the phosphodiesterase 5 and 10 tandem GAF domains.The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain.Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2.A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood.Sensory Repertoire of Bacterial Chemoreceptors.Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects.

P2860

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P2860

cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11

http://www.wikidata.org/entity/Q28285255

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2006年の論文

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cAMP is a ligand for the tande ...... domain of phosphodiesterase 11

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P1433

Journal of Biological Chemistry

P1476

cAMP is a ligand for the tande ...... domain of phosphodiesterase 11

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P2093

Anita Schultz

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Joachim E Schultz

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Jost Weber

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Karina Hofbauer

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Marco Gross-Langenhoff

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P2860

Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression

Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

SMART, a simple modular architecture research tool: identification of signaling domains

Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A

Cloning and characterization of two splice variants of human phosphodiesterase 11A

The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains

Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains

Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants

3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues

P304

2841-6

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scholarly article

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10.1074/JBC.M511468200

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P433

5

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P478

281

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P577

2006-02-03T00:00:00Z

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P698

16330539

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