Claspin, a regulator of Chk1 in DNA replication stress pathway
about
Chk1 suppressed cell deathRepeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin functionProteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationTimeless links replication termination to mitotic kinase activationNovel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Cell-cycle checkpoints and cancerAtaxin-3 promotes genome integrity by stabilizing Chk1.Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction.Genomic instability and cancer: lessons learned from human papillomaviruses.Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblastsMolecularly targeted therapies in non-small-cell lung cancer annual update 2014Claspin as a biomarker of human papillomavirus-related high grade lesions of uterine cervix.Repair of topoisomerase I-mediated DNA damage.Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts.Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment.Replicating damaged DNA in eukaryotes.Family cancer syndromes: inherited deficiencies in systems for the maintenance of genomic integrity.DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress responseAPC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.Understanding the limitations of radiation-induced cell cycle checkpoints.Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint functionMolecular and genomic approach for understanding the gene-environment interaction between Nrf2 deficiency and carcinogenic nickel-induced DNA damage.The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress.Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin.Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability.The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.Combining molecular dynamics simulation and ligand-receptor contacts analysis as a new approach for pharmacophore modeling: beta-secretase 1 and check point kinase 1 as case studies.Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1
P2860
Q21203552-08671A84-556D-4A9D-840D-F746908D4201Q24302160-A437EB36-D0DC-4E46-9294-A347E685F00AQ24307983-8AFD1965-6A1A-4B57-991A-25D5FA3193EDQ24670580-022EB131-5A09-49AB-BA58-CBD02C239E2AQ27342850-45C3D808-40BA-4D9D-B883-31779A330AB5Q28262425-5A571A62-9503-4194-8B1B-457A8523C4EDQ28293996-2E2AEF47-1150-4685-BEB1-9F62208E68ABQ33635896-EE759628-8C78-4765-A33C-902ABF59CFF3Q34293764-8DD6554B-37A8-45B5-8785-0B05E2060535Q34612265-5627135A-C47B-41BA-9DDB-E6D53F61824FQ35079332-786AEE9C-7F2C-4BF1-866F-6B990EFDCA8DQ35136424-6FDC4C7A-A883-456F-BB91-644752D17AFFQ36207038-8D3AD4C3-6842-4923-8980-713F69A51B0CQ36557533-4956BB3D-8945-49E4-99E2-F1DA906DA75EQ36891684-52979DB8-C49A-434F-9E83-0AB06610DCD3Q36947768-56950D86-D186-4DC6-997B-DB364CC1D5F9Q37340387-7A658922-017D-417A-9096-7E1CA4EC2C07Q37341109-211A74FE-01B5-420C-892F-25CA363E481DQ37701315-ABFC0C8F-9179-437A-902C-9794A119BAF8Q37799221-7F7505AD-82DD-45C4-827A-61E8E1AF3C39Q37869479-FC166FAC-B547-4DF9-BBFE-ADADB7201141Q38296672-8318082F-51CB-4346-9F0A-74F28D4A07D3Q39142830-21FC3689-CD27-4D5A-8534-CEBF2C72AF5BQ39268942-E9E69431-FE8D-4DD9-9D2A-7EEE4A8569B3Q40127820-7ECD90A7-581F-406C-8580-9D9940C3E71AQ40913003-8D64F73B-30C3-43C1-A6CF-2194702FF05CQ42111088-B53A5342-A53D-4D36-AD76-81498C723956Q42544432-9CD76D68-78D1-4AB1-B605-FA4C818C6420Q43248906-C47B975D-F1E1-46C2-9F78-5D0EA7ADFE5DQ50209871-ABE65F32-4763-4B9E-AC26-D3BAE84FE201Q51410824-BFFBA574-441D-4C02-BF70-7E9BDC2D1877Q56798186-8D92E295-9000-4942-83DF-6E95CB5EF387
P2860
Claspin, a regulator of Chk1 in DNA replication stress pathway
description
2004 nî lūn-bûn
@nan
2004 թուականին հրատարակուած գիտական յօդուած
@hyw
2004 թվականին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Claspin, a regulator of Chk1 in DNA replication stress pathway
@ast
Claspin, a regulator of Chk1 in DNA replication stress pathway
@en
Claspin, a regulator of Chk1 in DNA replication stress pathway
@nl
type
label
Claspin, a regulator of Chk1 in DNA replication stress pathway
@ast
Claspin, a regulator of Chk1 in DNA replication stress pathway
@en
Claspin, a regulator of Chk1 in DNA replication stress pathway
@nl
prefLabel
Claspin, a regulator of Chk1 in DNA replication stress pathway
@ast
Claspin, a regulator of Chk1 in DNA replication stress pathway
@en
Claspin, a regulator of Chk1 in DNA replication stress pathway
@nl
P1433
P1476
Claspin, a regulator of Chk1 in DNA replication stress pathway
@en
P2093
Claudia C S Chini
Junjie Chen
P304
P356
10.1016/J.DNAREP.2004.03.001
P407
P577
2004-01-01T00:00:00Z