Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability.
about
Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and ChemoresistanceThe Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human CancerGli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitorsDeficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesisIonizing Radiation Exposure and Basal Cell Carcinoma PathogenesisA novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cellsPromising Gene Therapeutics for Salivary Gland RadiotoxicityGli1 contributes to cellular resistance to cisplatin through altered cellular accumulation of the drug.Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers.Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancerRadiation induced non-targeted response: mechanism and potential clinical implications.Detection of canonical hedgehog signaling in breast cancer by 131-iodine-labeled derivatives of the sonic hedgehog protein.Ciliary abnormalities in senescent human fibroblasts impair proliferative capacityOncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activationWIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma.Hedgehog signaling and radiation induced liver injury: a delicate balance.Hedgehog signaling in prostate cancer and its therapeutic implicationGLI1 upregulates C-JUN through a specific 130-kDa isoformHedgehog signaling: networking to nurture a promalignant tumor microenvironment.Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma.The transcription factor Cux1 in cerebellar granule cell development and medulloblastoma pathogenesis.Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer.The oncogenic GLI transcription factors facilitate keratinocyte survival and transformation upon exposure to genotoxic agents.Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.Regulation of DNA damage following termination of Hedgehog (HH) survival signaling at the level of the GLI genes in human colon cancerRadiation-induced inflammatory cascade and its reverberating crosstalks as potential cause of post-radiotherapy second malignancies.Pathways to chromothripsis.Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1 +/- granule cell precursors after radiation injury.
P2860
Q26775006-F6111E71-7E67-45B8-8CAD-593AFBF775B8Q26801375-C87CA404-B545-4F20-84BD-5471A2EB98C1Q28248615-794660AE-E4F4-4443-B2AF-408FF7F05FB1Q28389106-043F2E90-2A35-46DB-846D-C94F91D11B06Q28391377-5C1F9C87-D58E-4BEA-A32A-C0483D88744AQ28546578-AE224FEA-5C8E-430A-B11F-BD0302ABB45FQ30361268-B4350BC0-1A40-49E8-A355-7023E63CF1A6Q33881681-8699D81E-A032-4BD1-8A11-B2C964FDF952Q34094337-A89BB681-AC71-438C-91BD-8ECAD08BBF25Q35160712-84981DA7-F2E5-43F5-939E-B636238A2C14Q35640296-CB4F94F4-7584-4929-ACBA-F6C34CF18AABQ35973897-58DCB1B8-3B30-44D5-B2E9-57D34A31D61FQ36091241-8900C9A0-7F40-4C40-BA61-A20A183AEDC1Q36183766-8831CB4A-860F-47AD-A5F2-B9597EE85C96Q36641703-97FE0819-77D6-4791-8E84-4579B835D4D8Q36714301-99B60DD6-362F-428A-A65E-7A5953CAE7F6Q36955776-3CB0E697-0261-46CF-99B1-345EC391F8AAQ37091887-E2D5831E-C43B-4B38-B321-A8C2BC73E2ADQ37591947-407090D1-1372-4A86-86C5-BFFE77EB7A88Q37903167-EE6BF035-8826-44BA-AA38-F5BAEEF48C82Q38281336-F99D5D30-EA83-4CCD-A759-CE977AECF48BQ38909519-C7E26EAD-D338-468B-9782-16A7742EA365Q38968446-8849048D-66FA-4E29-9F0B-E98D61226998Q39006737-3C3E109A-653C-4530-B39B-C2EC8BFD0F74Q39136441-2E66BB9F-E417-4D67-92CB-E2F628CFC2F8Q39205931-BD6D7921-9855-4F0B-B7C7-D483774EFA6DQ39253582-66E1F382-7AC4-4D38-90AE-868855F4DA8FQ39434440-B0D9A786-9643-49F2-8966-350A5ACFD961Q39983068-47280A91-AA9A-4474-B169-BDBE999B92CAQ46821523-D52363F8-1429-4767-8C9F-C0972F2CAD6F
P2860
Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Sonic Hedgehog signaling impai ...... d induces genomic instability.
@en
Sonic Hedgehog signaling impai ...... d induces genomic instability.
@nl
type
label
Sonic Hedgehog signaling impai ...... d induces genomic instability.
@en
Sonic Hedgehog signaling impai ...... d induces genomic instability.
@nl
prefLabel
Sonic Hedgehog signaling impai ...... d induces genomic instability.
@en
Sonic Hedgehog signaling impai ...... d induces genomic instability.
@nl
P2093
P2860
P356
P1476
Sonic Hedgehog signaling impai ...... d induces genomic instability.
@en
P2093
Cynthia Wetmore
Jennifer M Leonard
Larry M Karnitz
P2860
P304
P356
10.1083/JCB.200804042
P407
P577
2008-10-27T00:00:00Z