A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.
about
Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65The RAG1 N-terminal domain is an E3 ubiquitin ligaseAmino acid residues in RAG1 responsible for the interaction with RAG2 during the V(D)J recombination processStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisDNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining systemPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Recombination-activating gene proteins: more regulation, pleaseThe taming of a transposon: V(D)J recombination and the immune systemSelf-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.Thermal dependency of RAG1 self-association properties.Postcleavage sequence specificity in V(D)J recombination.Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines.The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombinationA C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.Functional organization of single and paired V(D)J cleavage complexesThe RAG proteins in V(D)J recombination: more than just a nuclease.Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinaseAssembly of the RAG1/RAG2 synaptic complexA RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals.Integrating prokaryotes and eukaryotes: DNA transposases in light of structure.The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes.Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.The bounty of RAGs: recombination signal complexes and reaction outcomes.V(D)J recombination: how to tame a transposase.Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.Histone methylation and V(D)J recombination.The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoireFull-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration.RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy.EGFR Intron Recombination in Human Gliomas: Inappropriate Diversion of V(D)J Recombination?A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.Solution conformations of early intermediates in Mos1 transpositionDeletion and tandem duplication of exons 2 - 7 in the epidermal growth factor receptor gene of a human malignant glioma.
P2860
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P2860
A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.
@ast
A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.
@en
type
label
A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.
@ast
A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.
@en
prefLabel
A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.
@ast
A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.
@en
P2093
P2860
P356
P1476
A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.
@en
P2093
P2860
P304
P356
10.1128/MCB.19.7.4664
P407
P577
1999-07-01T00:00:00Z