Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism - Wikidata - awgldk - TriplyDB

Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism

Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism

http://www.wikidata.org/entity/Q28281609

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TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation Vinpocetine as a potent antiinflammatory agent A novel compound C12 inhibits inflammatory cytokine production and protects from inflammatory injury in vivo Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media Inhibitory effects of vinpocetine on the progression of atherosclerosis are mediated by Akt/NF-κB dependent mechanisms in apoE-/- mice Vinpocetine attenuates neointimal hyperplasia in diabetic rat carotid arteries after balloon injury.Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation.Berberine ameliorates chronic kidney injury caused by atherosclerotic renovascular disease through the suppression of NFκB signaling pathway in rats.Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus.Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1 Shuang-huang-lian attenuates lipopolysaccharide-induced acute lung injury in mice involving anti-inflammatory and antioxidative activities.Vinpocetine reduces carrageenan-induced inflammatory hyperalgesia in mice by inhibiting oxidative stress, cytokine production and NF-κB activation in the paw and spinal cord.Vinpocetine inhibits amyloid-beta induced activation of NF-κB, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity.EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers.Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats Cyclic nucleotide phosphodiesterase 1 and vascular aging Anti-inflammatory effects of dabrafenib in vitro and in vivo.Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration.Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD.Vinpocetine attenuates lipid accumulation and atherosclerosis formation.The Rho/Rho-associated protein kinase inhibitor fasudil in the protection of endothelial cells against advanced glycation end products through the nuclear factor κB pathway.Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short.Clinical and molecular genetics of the phosphodiesterases (PDEs).The role of inflammation in the pathogenesis of lung cancer.PDE1 isozymes, key regulators of pathological vascular remodeling Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments.Anti-inflammatory effects of vinpocetine in atherosclerosis and ischemic stroke: a review of the literature.Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients.Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system.Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Anti-inflammatory effects of kolaviron modulate the expressions of inflammatory marker genes, inhibit transcription factors ERK1/2, p-JNK, NF-κB, and activate Akt expressions in the 93RS2 Sertoli cell lines.In vitro characterization of transport and metabolism of the alkaloids: vincamine, vinpocetine and eburnamonine.Trehalose alleviates PC12 neuronal death mediated by lipopolysaccharide-stimulated BV-2 cells via inhibiting nuclear transcription factor NF-κB and AP-1 activation.Vinpocetine Inhibited the CpG Oligodeoxynucleotide-induced Immune Response in Plasmacytoid Dendritic Cells.Vinpocetine inhibits breast cancer cells growth in vitro and in vivo.Vinpocetine inhibits oligodendroglial precursor cell differentiation.Shp2 Deficiency Impairs the Inflammatory Response Against Haemophilus influenzae by Regulating Macrophage Polarization.

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Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism

http://www.wikidata.org/entity/Q28281609

description

2010 nî lūn-bûn

@nan

2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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type

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Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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prefLabel

Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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Proceedings of the National Academy of Sciences of the United States of America

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Vinpocetine inhibits NF-kappaB ...... but PDE-independent mechanism

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Bradford C Berk

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Chen Yan

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Dong-Seok Kwon

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Hirofumi Jono

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Jae Hyang Lim

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Jian-Dong Li

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Jun-Ichi Abe

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Kye-Im Jeon

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Toru Aizawa

http://www.w3.org/2001/XMLSchema#string

Xiangbin Xu

http://www.w3.org/2001/XMLSchema#string

P2860

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase

IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

Neuroprotective effect of sodium channel blockers in ischemia: the pathomechanism of early ischemic dysfunction

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate

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