The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials
about
Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoringHemozoin and antimalarial drug discoveryInsights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex.1,2-disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents.Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs.The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitor1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agentsA physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs.Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.Recent advances in the discovery of haem-targeting drugs for malaria and schistosomiasis.Arylmethylamino steroids as antiparasitic agents.Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Structure of malaria pigment and related propanoate-linked metalloporphyrin dimers.Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter.Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines.Artemisinin and its derivatives in treating protozoan infections beyond malaria.High-Throughput Screening and Prediction Model Building for Novel Hemozoin Inhibitors Using Physicochemical Properties.Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography.Molecular modeling and evaluation of binding mode and affinity of artemisinin-quinine hybrid and its congeners with Fe-protoporphyrin-IX as a putative receptorDeconstructing Quinoline-Class Antimalarials to Identify Fundamental Physicochemical Properties of Beta-Hematin Crystal Growth Inhibitors.Orienting the heterocyclic periphery: a structural model for chloroquine's antimalarial activity.Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.Beyond heme detoxification: a role for hemozoin in iron transport in S. japonicum.Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action.A computational study of ligand binding affinities in iron(III) porphine and protoporphyrin IX complexes.Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution.Revisiting the Therapeutic Potential of Bothrops jararaca Venom: Screening for Novel Activities Using Connectivity Mapping.Molecular modeling study of a series of amodiaquine analogues with antimalarial activity
P2860
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P2860
The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The crystal structure of halof ...... of arylmethanol antimalarials
@ast
The crystal structure of halof ...... of arylmethanol antimalarials
@en
The crystal structure of halof ...... of arylmethanol antimalarials
@nl
type
label
The crystal structure of halof ...... of arylmethanol antimalarials
@ast
The crystal structure of halof ...... of arylmethanol antimalarials
@en
The crystal structure of halof ...... of arylmethanol antimalarials
@nl
prefLabel
The crystal structure of halof ...... of arylmethanol antimalarials
@ast
The crystal structure of halof ...... of arylmethanol antimalarials
@en
The crystal structure of halof ...... of arylmethanol antimalarials
@nl
P1476
The crystal structure of halof ...... of arylmethanol antimalarials
@en
P2093
Katherine A de Villiers
Timothy J Egan
P304
P356
10.1016/J.JINORGBIO.2008.04.001
P407
P577
2008-04-20T00:00:00Z