Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility
about
Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptorUse of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasisMUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of metSelected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptorHepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesisSustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesisSignaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKLGab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signalingActivation of Ras/Erk pathway by a novel MET-interacting protein RanBPMViable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar developmentCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesMet receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodiaInvolvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growthHepatocyte Growth Factor/scatter factor-induces phosphorylation of cortactin in A431 cells in a Src kinase-independent manner.Hepatocyte Growth Factor/C-Met Axis in Thyroid Cancer: From Diagnostic Biomarker to Therapeutic TargetHepatocyte growth factor, a versatile signal for developing neurons.A point mutation in the MET oncogene abrogates metastasis without affecting transformation.Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis.Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.Invasive growth: from development to metastasisConditional activation of MET in differentiated skeletal muscle induces atrophy.Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons.Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.Aptamers Binding to c-Met Inhibiting Tumor Cell MigrationErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis.Paracrine effects of hepatocyte growth factor/scatter factor on non-small-cell lung carcinoma cell lines.Constitutive activation of the RON gene promotes invasive growth but not transformation.The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesisThe multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering.MET receptor tyrosine kinase as an autism genetic risk factor.Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase.Src-mediated activation of alpha-diacylglycerol kinase is required for hepatocyte growth factor-induced cell motility.The tyrosine kinase receptor c-met, its cognate ligand HGF and the tyrosine kinase receptor trasducers STAT3, PI3K and RHO in thyroid nodules associated with Hashimoto's thyroiditis: an immunohistochemical characterization.c-Met expression is regulated by Mitf in the melanocyte lineage.The tyrosines in the bidentate motif of the env-sea oncoprotein are essential for cell transformation and are binding sites for Grb2 and the tyrosine phosphatase SHP-2.MET genetic lesions in non-small-cell lung cancer: pharmacological and clinical implications.Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.Met-driven invasive growth involves transcriptional regulation of Arhgap12.
P2860
Q24291722-894D54DF-F5CD-4587-8BE1-3B374ADEA8ACQ24292477-B1C3D49C-C6B9-41F0-B1B8-C810482D25CDQ24301503-11673B08-ADC7-42B0-8AD9-0C0BE705CFB8Q24307890-330B3D49-8F46-4F8B-B3A3-E6BD567ADB4CQ24329131-A0E810E7-0271-45A6-AF87-4F681E35FD30Q24532160-181336C8-167A-42D1-9932-FC66D428765DQ28139783-621D612A-4AA9-41A4-9763-8256998A2CFFQ28141139-2A536B53-B41C-4F38-BB2C-3DC19D75CFFDQ28213808-8990F026-30FE-4C7D-B8B9-1F74BA816BFAQ28216348-317D35C7-BC10-45D0-8DBF-ECDE1D91B588Q28507121-3B70400F-94C5-4FDF-ADEF-41410C6DBF50Q28513246-D135B89C-BBF8-40DB-B465-EE82C1498384Q30010161-29D8E8F7-B8D9-46EC-A5E6-07C472439AA0Q30156817-0602EB8F-F704-47A5-9648-238310418DBBQ30168070-32673AE7-6273-496C-BEDB-207674BE6088Q33565746-2240B953-AB71-4343-83B3-562677318A6EQ33589398-E0945908-0A83-40AB-A107-342C6AA59162Q33731936-80D2D46B-8A04-4EE6-9635-88A0714A02F4Q33786959-0494775A-9F48-4634-BE53-6E06CE235943Q34434226-4421DEC2-1C57-41F5-A469-857223AB0300Q34584035-7A01A53F-D1D8-4CA8-9E83-2E7ABB99ABE4Q34595811-F4FD11DB-2329-40B3-A70B-D63E7F39ABDBQ35010265-3BE5929C-6F25-424C-BB4B-03CFF93B69B5Q35199939-7083A33B-822A-4987-BEB5-F2FC43B60B26Q35753150-96B864CE-3AD2-4B3F-97E5-2A78929C31FBQ35866739-7092722B-CEBF-466D-B836-F1A043F5F467Q36095732-BEEA6F54-3C69-4A6C-AB47-277EA0295A3DQ36292961-3A8E0ACC-0891-4EE5-B9B5-EDC8BC44B171Q36564393-8AF1C44E-EBDA-4137-B3DA-2C515A0B53A4Q36601812-BFE45839-E256-4EB5-877D-B0716F97CF03Q36843122-7897BB7C-4BA4-4191-B692-1EB3E38F5D56Q38167461-F5B8ED19-E1A5-4CDA-AC45-5F382C3E3194Q38302515-DF1E3322-FBA3-4F97-AA1F-26BF4C91B157Q38308665-656290A4-A861-4871-A784-E40BCCA5D7F9Q38313083-767C8CA7-9A2E-4660-B328-6F4C6FD02270Q38316196-3D86D870-572F-4A15-AA6E-83831EAAA974Q38327407-FA193D91-5179-4379-B6A9-0E9306661407Q38389999-245B7117-B211-436D-AF1B-167AA4753683Q38422783-1740C816-1379-45A1-87A5-C26F87598B30Q39978520-5F416338-69D4-44F2-9450-58DBAAC30A92
P2860
Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Specific uncoupling of GRB2 fr ...... on transformation and motility
@ast
Specific uncoupling of GRB2 fr ...... on transformation and motility
@en
Specific uncoupling of GRB2 fr ...... on transformation and motility
@nl
type
label
Specific uncoupling of GRB2 fr ...... on transformation and motility
@ast
Specific uncoupling of GRB2 fr ...... on transformation and motility
@en
Specific uncoupling of GRB2 fr ...... on transformation and motility
@nl
prefLabel
Specific uncoupling of GRB2 fr ...... on transformation and motility
@ast
Specific uncoupling of GRB2 fr ...... on transformation and motility
@en
Specific uncoupling of GRB2 fr ...... on transformation and motility
@nl
P2093
P356
P1476
Specific uncoupling of GRB2 fr ...... on transformation and motility
@en
P2093
C Ponzetto
M L Basile
P Comoglio
R Narsimhan
P304
14119-14123
P356
10.1074/JBC.271.24.14119
P407
P577
1996-06-01T00:00:00Z