SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events
about
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndromePUMA, a potent killer with or without p53Sp1 and p73 activate PUMA following serum starvationAntagonistic regulation of apoptosis and differentiation by the Cut transcription factor represents a tumor-suppressing mechanism in DrosophilaSmac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathwayAurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells.PUMA decreases the growth of prostate cancer PC-3 cells independent of p53.Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis.PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cellsThe role of death-associated protein 3 in apoptosis, anoikis and human cancerPotential therapeutic benefits of strategies directed to mitochondria.NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatinPUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.Identification of BIRC6 as a novel intervention target for neuroblastoma therapy.The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growthBasal metabolic state governs AIF-dependent growth support in pancreatic cancer cells.Caspase-9 mediates Puma activation in UCN-01-induced apoptosis.The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells.Crizotinib induces PUMA-dependent apoptosis in colon cancer cells.Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.Radiation-induced cytochrome c release and the neuroprotective effects of the pan-caspase inhibitor z-VAD-fmk in the hypoglossal nucleus.Experimental study on the inhibitory effect of sodium cantharidinate on human hepatoma HepG2 cells.PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy.Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis.Targeting SLUG sensitizes leukemia cells to ADR-induced apoptosis.Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner.AD-O53.2--a novel recombinant fusion protein combining the activities of TRAIL/Apo2L and Smac/Diablo, overcomes resistance of human cancer cells to TRAIL/Apo2L.SLUG is activated by nuclear factor kappa B and confers human alveolar epithelial A549 cells resistance to tumor necrosis factor-alpha-induced apoptosisPromotion of Caspase Activation by Caspase-9-mediated Feedback Amplification of Mitochondrial Damage.JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells.Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death.Identification of thymidylate synthase as a potential therapeutic target for lung cancer.Etoposide induces protein kinase Cdelta- and caspase-3-dependent apoptosis in neuroblastoma cancer cells.PUMA suppresses intestinal tumorigenesis in mice.
P2860
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P2860
SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@ast
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@en
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@nl
type
label
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@ast
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@en
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@nl
prefLabel
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@ast
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@en
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@nl
P2093
P2860
P3181
P356
P1433
P1476
SMAC/Diablo mediates the proap ...... A-induced mitochondrial events
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1210196
P407
P577
2007-01-22T00:00:00Z
P5875
P6179
1004994076