IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits
about
CaMKII regulation of cardiac K channelsThe KCNQ1 channel - remarkable flexibility in gating allows for functional versatilityKCNQ1 channel modulation by KCNE proteins via the voltage-sensing domainIndividual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits.KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two stepsLQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms.Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channelIdentification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity.KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulationKv7.1 ion channels require a lipid to couple voltage sensing to pore opening.The α2δ-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentialsBuilding KCNQ1/KCNE1 channel models and probing their interactions by molecular-dynamics simulations.Stoichiometry of the cardiac IKs complex.Ion channel engineering: perspectives and strategies.Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channelVoltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations.Cardiac Delayed Rectifier Potassium Channels in Health and Disease.Molecular Pathophysiology of Congenital Long QT Syndrome.Chansporter complexes in cell signaling.Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4.SUMOylation determines the voltage required to activate cardiac IKs channels.Upregulation of KCNQ1/KCNE1 K+ channels by Klotho.PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels.Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening.
P2860
Q26864362-34EEADDF-6202-4708-89CC-B3E6D71B5722Q27013934-76D56DDE-4896-48FB-B54A-B7CA6CACE9DEQ27027928-E2FDC61A-2CD0-45E9-B6AB-AD1CE4E23752Q28235159-AA057356-B55C-4E7B-984E-9E571BE94207Q33603925-BA8100A8-196F-493C-BE13-E4C74A912AD7Q34974496-ED4898F9-EB99-48B2-BDF3-58AE2D10B854Q35240329-3D56580C-B626-4BDF-A6DA-F267516AABE4Q36744608-2FB4B0C4-67B2-46E3-B789-3A1BC1DA6CD5Q37028794-2577DE0F-B8A0-4EAD-9963-C88B253EA490Q37088789-19E62791-5D1B-4E16-9327-AD9FCD253267Q37145014-FBDF9ED7-BCBB-43C3-8B97-036CB2537283Q37371847-78A8663C-D345-4534-988D-BCFADFBA1DD5Q37702028-89661360-456F-4DE0-802C-2EE90F04AD88Q38247898-8753D2BA-3183-45EE-9C32-698DE204044FQ38632751-631F3DDF-CA75-4C0D-97DF-5260DE31C42CQ38690407-C8E338F2-B10F-42EF-B0CB-8C99C001020BQ38805694-47F75721-7711-4894-92B8-4E376BEF0128Q38854252-AB782A44-8825-426D-8E9A-374B7462B444Q38997049-FE01894E-E14A-45C7-841D-F476050FA68BQ39441418-9C0DB930-9EBE-496B-9B4A-AAAAC2AA6323Q39477676-FB3CE44C-AF7B-4F70-B06E-09AE3C26EC16Q41433606-CA5106EA-A58D-4929-9260-F484CAF81928Q41858909-251870A0-B886-42B5-A7F9-0D7B784E8294Q46335684-9A3B0D74-EDE8-4B49-8116-349C9008B138Q53042866-5681DDE3-729A-4D98-93EE-F4FE0429EF49
P2860
IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
name
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@ast
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@en
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@nl
type
label
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@ast
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@en
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@nl
prefLabel
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@ast
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@en
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@nl
P2093
P2860
P3181
P356
P1476
IKs channels open slowly becau ...... in KCNQ1 pore-forming subunits
@en
P2093
Carlos A Villalba-Galea
Francisco Bezanilla
Katarina J Ruscic
Yukiko Mishina
P2860
P304
P3181
P356
10.1073/PNAS.1222616110
P407
P577
2013-01-28T00:00:00Z