about
Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human spermA homotropic two-state model and auto-antagonismPrinciples of allosteric interactions in cell signalingFluorescent approaches for understanding interactions of ligands with G protein coupled receptorsConstitutively active rhodopsin and retinal diseaseAgonist induction, conformational selection, and mutant receptorsConstitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonistsConstitutively active mutants of 5-HT4 receptors are they in unique active states?BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activityHigh-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist actionTrade-offs and constraints in allosteric sensingA unified view of "how allostery works"Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes.Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.Evolution of sparsity and modularity in a model of protein allostery.The power of mass spectrometry in structural characterization of GPCR signaling.Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.On the fitting of binding data when receptor dimerization is suspected.In vivo imaging of cerebral dopamine D3 receptors in alcoholism.Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum.Nanobodies to Study G Protein-Coupled Receptor Structure and Function.Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery.H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects.Protean agonism at histamine H3 receptors in vitro and in vivoThe surmountable effect of FSCPX, an irreversible A(1) adenosine receptor antagonist, on the negative inotropic action of A(1) adenosine receptor full agonists in isolated guinea pig left atria.The histamine H3 receptor: from gene cloning to H3 receptor drugs.Genetic variations in human G protein-coupled receptors: implications for drug therapy.Functional methods for quantifying agonists and antagonists.Allosteric transition: a comparison of two modelsCannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor.Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activationDecoding the dopamine signal in macaque prefrontal cortex: a simulation study using the Cx3Dp simulatorCardiac-specific overexpression of human beta2 adrenoceptors in mice exposes coupling to both Gs and Gi proteinsMultiple-targeting and conformational selection in the estrogen receptor: computation and experiment.Efficacy in CB1 receptor-mediated signal transductionStudies using isolated uterine and other preparations show bimatoprost and prostanoid FP agonists have different activity profiles.Conformational selection and equilibrium governs the ability of retinals to bind opsin.Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.Allosteric modulation of the M₃ muscarinic receptor by amiodarone and N-ethylamiodarone: application of the four-ligand allosteric two-state model.
P2860
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P2860
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
The two-state model of receptor activation
@ast
The two-state model of receptor activation
@en
The two-state model of receptor activation
@nl
type
label
The two-state model of receptor activation
@ast
The two-state model of receptor activation
@en
The two-state model of receptor activation
@nl
prefLabel
The two-state model of receptor activation
@ast
The two-state model of receptor activation
@en
The two-state model of receptor activation
@nl
P1476
The two-state model of receptor activation
@en
P2093
P356
10.1016/S0165-6147(00)88989-0
P407
P577
1995-03-01T00:00:00Z