Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity
about
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivationThe distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesisDirect association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytesEngagement of Gab1 and Gab2 in erythropoietin signalingThe SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptorA new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptorRole of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activityErythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activationSrc transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase.Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and AktErythropoietin and erythropoietin receptor.Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins.Epo regulates erythroid proliferation and differentiation through distinct signaling pathways: implication for erythropoiesis and Friend virus-induced erythroleukemia.Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo.Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal.Thrombopoietin: a tool for understanding thrombopoiesis.Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathwaysSelective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies.Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation.Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.Acute neuroprotective synergy of erythropoietin and insulin-like growth factor IErythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway.Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail.Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia.The erythropoietin receptor: molecular structure and hematopoietic signaling pathways.Activation of target signal transducers utilizing chimeric receptors with signaling-molecule binding motifs.Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways.Tissue inhibitor of metalloproteinases-1 signalling pathway leading to erythroid cell survival.A functional green fluorescent protein-erythropoietin receptor despite physical separation of JAK2 binding site and tyrosine residues.TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway.Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors.Protein kinase C alpha controls erythropoietin receptor signaling.Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a friend murine leukemia cell line.Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain.The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells--signals emanating from the erythropoietin receptor.The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway.
P2860
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P2860
Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@ast
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@en
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@nl
type
label
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@ast
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@en
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@nl
prefLabel
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@ast
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@en
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@nl
P2093
P2860
P356
P1476
Phosphorylation of tyrosine 50 ...... ssociated PI 3-kinase activity
@en
P2093
P2860
P304
P356
10.1074/JBC.270.40.23402
P407
P577
1995-10-06T00:00:00Z