Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1
about
Cardiac troponin mutations and restrictive cardiomyopathyHigh calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibitionIntegration of troponin I phosphorylation with cardiac regulatory networksCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeAdditional PKA phosphorylation sites in human cardiac troponin IRole of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytesTransgenic incorporation of skeletal TnT into cardiac myofilaments blunts PKC-mediated depression of forcePhosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocityInhibition of PKC phosphorylation of cTnI improves cardiac performance in vivoPhosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytesWhy does troponin I have so many phosphorylation sites? Fact and fancyPhosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament propertiesDephosphorylation specificities of protein phosphatase for cardiac troponin I, troponin T, and sites within troponin T.Altered cross-bridge characteristics following haemodynamic overload in rabbit hearts expressing V3 myosinIschemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sitesDifferential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile responseRole of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylationPhosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments.Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sitesLeft ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein CPhysiological roles of taurine in heart and muscleQuantification of protein phosphorylation by liquid chromatography-mass spectrometry.Deciphering modifications in swine cardiac troponin I by top-down high-resolution tandem mass spectrometry.Molecular actions of drugs that sensitize cardiac myofilaments to Ca2+.PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylationAugmented phosphorylation of cardiac troponin I in hypertensive heart failure.Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.Negative charges at protein kinase C sites of troponin I stabilize the inactive state of actinMolecular defects in cardiac myofibrillar proteins due to thyroid hormone imbalance and diabetes.Heart failure, myocardial stunning, and troponin: a key regulator of the cardiac myofilament.Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy.Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase APresent and future biochemical markers for detection of acute coronary syndrome.Myofilament incorporation and contractile function after gene transfer of cardiac troponin I Ser43/45Ala.Functionally conservative substitutions at cardiac troponin I S43/45.
P2860
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P2860
Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@ast
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@en
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@nl
type
label
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@ast
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@en
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@nl
prefLabel
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@ast
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@en
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@nl
P2093
P3181
P356
P1476
Cardiac troponin I mutants. Ph ...... f reconstituted actomyosin S-1
@en
P2093
N M Jideama
R J Solaro
R L Raynor
T A Noland
V Averyhart-Fullard
P304
P3181
P356
10.1074/JBC.270.43.25445
P407
P577
1995-10-27T00:00:00Z