Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein C
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How do MYBPC3 mutations cause hypertrophic cardiomyopathy?Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutationsMyocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardiumMyosin binding protein C interaction with actin: characterization and mapping of the binding site.Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation.Cardiac function is regulated by B56α-mediated targeting of protein phosphatase 2A (PP2A) to contractile relevant substrates.Diastolic myofilament dysfunction in the failing human heart.Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils.A-kinase anchoring proteins: scaffolding proteins in the heart.Magnitude of length-dependent changes in contractile properties varies with titin isoform in rat ventricles.Length and PKA Dependence of Force Generation and Loaded Shortening in Porcine Cardiac MyocytesMyosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-CCardiac myosin binding protein-C restricts intrafilament torsional dynamics of actin in a phosphorylation-dependent manner.Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytesCardiac Myosin Binding Protein-C Phosphorylation Modulates Myofilament Length-Dependent ActivationThe role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.In vivo cardiac myosin binding protein C gene transfer rescues myofilament contractile dysfunction in cardiac myosin binding protein C null miceMast cells regulate myofilament calcium sensitization and heart function after myocardial infarction.Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.β-Arrestin mediates the Frank-Starling mechanism of cardiac contractilitycMyBP-C as a promiscuous substrate: phosphorylation by non-PKA kinases and its potential significance.Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships.Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart.Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or β1-Adrenergic Stimulation.Cardiac myosin binding protein C and its phosphorylation regulate multiple steps in the cross-bridge cycle of muscle contraction.β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model.Functional dissection of myosin binding protein C phosphorylation.N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations.Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling.Identifying a role of the actin capping protein CapZ in β-adrenergic receptor signalling.Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms.Cardiac contraction, calcium transients, and myofilament calcium sensitivity fluctuate with the estrous cycle in young adult female mice.Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
P2860
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P2860
Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein C
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Protein kinase A-induced myofilament desensitization to Ca
@nl
Protein kinase A-induced myofi ...... rdiac myosin-binding protein C
@ast
Protein kinase A-induced myofi ...... rdiac myosin-binding protein C
@en
type
label
Protein kinase A-induced myofilament desensitization to Ca
@nl
Protein kinase A-induced myofi ...... rdiac myosin-binding protein C
@ast
Protein kinase A-induced myofi ...... rdiac myosin-binding protein C
@en
prefLabel
Protein kinase A-induced myofilament desensitization to Ca
@nl
Protein kinase A-induced myofi ...... rdiac myosin-binding protein C
@ast
Protein kinase A-induced myofi ...... rdiac myosin-binding protein C
@en
P2093
P2860
P356
P1476
Protein kinase A-induced myofi ...... rdiac myosin-binding protein C
@en
P2093
Inna N Rybakova
Jeffery W Walker
Jitandrakumar R Patel
Peter P Chen
Richard L Moss
P2860
P304
P356
10.1085/JGP.201010448
P577
2010-12-01T00:00:00Z