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Conformational switching of the 26S proteasome enables substrate degradation

Conformational switching of the 26S proteasome enables substrate degradation

http://www.wikidata.org/entity/Q28292908

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Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death Ubiquitin modifications Characterizing the dynamics of proteasome complexes by proteomics approaches Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate.Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11 Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation Crystal structure of the human COP9 signalosome An atomic structure of the human 26S proteasome Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.Perilous journey: a tour of the ubiquitin-proteasome system Regulation of proteasome activity in health and disease Bacterial proteasome activator bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasome Solution structure of yeast Rpn9: insights into proteasome lid assembly Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast Molecular snapshots of the Pex1/6 AAA+ complex in action.Architecture and assembly of the archaeal Cdc48*20S proteasome Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.Modelling proteasome and proteasome regulator activities.Glatiramer acetate and nanny proteins restrict access of the multiple sclerosis autoantigen myelin basic protein to the 26S proteasome Inherent asymmetry in the 26S proteasome is defined by the ubiquitin receptor RPN13 Paradigms of protein degradation by the proteasome.PiZ mouse liver accumulates polyubiquitin conjugates that associate with catalytically active 26S proteasomes Regulated protein turnover: snapshots of the proteasome in action.Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX Base-CP proteasome can serve as a platform for stepwise lid formation Substrate degradation by the proteasome: a single-molecule kinetic analysis.N-Terminal Coiled-Coil Structure of ATPase Subunits of 26S Proteasome Is Crucial for Proteasome Function Gates, Channels, and Switches: Elements of the Proteasome Machine Structural characterization of the interaction of Ubp6 with the 26S proteasome.Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21 Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly.Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation Structure of an endogenous yeast 26S proteasome reveals two major conformational states Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.

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P2860

Conformational switching of the 26S proteasome enables substrate degradation

http://www.wikidata.org/entity/Q28292908

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2013 nî lūn-bûn

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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Conformational switching of the 26S proteasome enables substrate degradation

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Conformational switching of the 26S proteasome enables substrate degradation

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Conformational switching of the 26S proteasome enables substrate degradation

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type

label

Conformational switching of the 26S proteasome enables substrate degradation

@ast

Conformational switching of the 26S proteasome enables substrate degradation

@en

Conformational switching of the 26S proteasome enables substrate degradation

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prefLabel

Conformational switching of the 26S proteasome enables substrate degradation

@ast

Conformational switching of the 26S proteasome enables substrate degradation

@en

Conformational switching of the 26S proteasome enables substrate degradation

@nl

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Nature Structural & Molecular Biology

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Conformational switching of the 26S proteasome enables substrate degradation

@en

P2093

Mary E Matyskiela

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P2860

A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes

Sem1p is a novel subunit of the 26 S proteasome from Saccharomyces cerevisiae

Recognition of the polyubiquitin proteolytic signal

Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases

Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry

Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

A gated channel into the proteasome core particle

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

Structural Insights into the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschii

Running in Reverse: The Structural Basis for Translocation Polarity in Hexameric Helicases

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762157

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10.1038/NSMB.2616

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7

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20

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Gabriel C. Lander

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2013-06-16T00:00:00Z

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239525038

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23770819

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structural biology

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3712289

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