A low-barrier hydrogen bond in the catalytic triad of serine proteases
about
Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesIdentification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginineHydrogen bonding in water using synthetic receptorsComplete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificityOn the electronic nature of low-barrier hydrogen bonds in enzymatic reactionsBiochemistry and theory of proton-coupled electron transferProton transfer reactions and hydrogen-bond networks in protein environmentsBreaking the low barrier hydrogen bond in a serine proteaseCrystal structure of delta(5)-3-ketosteroid isomerase from Pseudomonas testosteroni in complex with equilenin settles the correct hydrogen bonding scheme for transition state stabilizationInhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domainAlternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexesDetection of large pKa perturbations of an inhibitor and a catalytic group at an enzyme active site, a mechanistic basis for catalytic power of many enzymes'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexesStructural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: Function of the Asn-His interaction in the catalytic triadX-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolutionTrypsin revisited: crystallography AT (SUB) atomic resolution and quantum chemistry revealing details of catalysisStructure of a serine protease poised to resynthesize a peptide bondShort strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase.Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion HoleLow-barrier hydrogen bond in photoactive yellow proteinStructure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallographyA neutron crystallographic analysis of T6porcine insulin at 2.1 Å resolutionUltrahigh (0.93Å) resolution structure of manganese peroxidase from Phanerochaete chrysosporium: Implications for the catalytic mechanismThe catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease actionStructural insights into the proton pumping by unusual proteorhodopsin from nonmarine bacteriaProtonation-state determination in proteins using high-resolution X-ray crystallography: effects of resolution and completenessAtomic resolution structure of a lysine-specific endoproteinase from Lysobacter enzymogenes suggests a hydroxyl group bound to the oxyanion holeThe reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complexInsights into transition state stabilization of the beta-1,4-glycosidase Cex by covalent intermediate accumulation in active site mutantsUnconventional serine proteases: variations on the catalytic Ser/His/Asp triad configurationEnergy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bondsMutation of residues 423 (Met/Ile), 444 (Thr/Met), and 506 (Asn/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinaseNMR Spectroscopic Characterization of Charge Assisted Strong Hydrogen Bonds in Brønsted Acid CatalysisCharacterization of Bafinivirus main protease autoprocessing activities.Unusual 1H NMR chemical shifts support (His) C(epsilon) 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis.alpha-lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities.Proton bridging in the interactions of thrombin with hirudin and its mimics.Bare histidine-serine models: implication and impact of hydrogen bonding on nucleophilicity.Vibrational Stark Effects of Carbonyl Probes Applied to Reinterpret IR and Raman Data for Enzyme Inhibitors in Terms of Electric Fields at the Active SiteFractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin
P2860
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P2860
A low-barrier hydrogen bond in the catalytic triad of serine proteases
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@ast
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@en
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@nl
type
label
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@ast
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@en
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@nl
prefLabel
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@ast
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@en
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@nl
P2093
P356
P1433
P1476
A low-barrier hydrogen bond in the catalytic triad of serine proteases
@en
P2093
P304
P356
10.1126/SCIENCE.7661899
P407
P577
1994-06-24T00:00:00Z