Unusual 1H NMR chemical shifts support (His) C(epsilon) 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis.
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Carbon-oxygen hydrogen bonding in biological structure and functionX-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolutionSolution structure of an atypical WW domain in a novel beta-clam-like dimeric formStructure of a serine protease poised to resynthesize a peptide bondRevisiting the mechanism of the triosephosphate isomerase reaction: the role of the fully conserved glutamic acid 97 residueCrystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important ResiduesThe Structure of the Karrikin-Insensitive Protein (KAI2) in Arabidopsis thalianaFunctional and structural characterization of a thermostable acetyl esterase from Thermotoga maritimaStructure of a proteolytically resistant analogue of (NLys)5SFTI-1 in complex with trypsin: evidence for the direct participation of the Ser214 carbonyl group in serine protease-mediated proteolysisUnconventional serine proteases: variations on the catalytic Ser/His/Asp triad configurationTorsional and Electronic Factors Control the C-H⋅⋅⋅O InteractionImidazole C-2 hydrogen/deuterium exchange reaction at histidine for probing protein structure and function with matrix-assisted laser desorption ionization mass spectrometry.Unraveling the stereochemical and dynamic aspects of the catalytic site of bacterial peptidyl-tRNA hydrolase.alpha-lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities.Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase.The structural basis of a conserved P2 threonine in canonical serine proteinase inhibitors.Strength of the Calpha H..O hydrogen bond of amino acid residues.Mechanisms of proton conduction and gating in influenza M2 proton channels from solid-state NMRCatalytic reaction mechanism of acetylcholinesterase determined by Born-Oppenheimer ab initio QM/MM molecular dynamics simulations.Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates.Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9Serine protease acylation proceeds with a subtle re-orientation of the histidine ring at the tetrahedral intermediate.Tautomerism, acid-base equilibria, and H-bonding of the six histidines in subtilisin BPN' by NMRAn Intramolecular CAr-H•••O=C Hydrogen Bond and the Configuration of Rotenoids.Spatial distribution of dielectric shielding in the interior of Pyrococcus furiosus rubredoxin as sampled in the subnanosecond timeframe by hydrogen exchange.Conformational preferences of monohydrated clusters of imidazole derivatives revisited.Modeling temperature dependent kinetic isotope effects for hydrogen transfer in a series of soybean lipoxygenase mutants: The effect of anharmonicity upon transfer distance.Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases.NMR studies of the hydrogen bonds involving the catalytic triad of Escherichia coli thioesterase/protease I.Mechanistic insights from molecular dynamic simulation of Rv0045c esterase in Mycobacterium tuberculosis.Complete backbone and DENQ side chain NMR assignments in proteins from a single experiment: implications to structure-function studies.The solution of nitrogen inversion in amidases.ω-Turn: a novel β-turn mimic in globular proteins stabilized by main-chain to side-chain C−H···O interaction.CH···O Hydrogen Bonds at Protein-Protein InterfacesStructural Analyses on Intermediates in Serine Protease Catalysis
P2860
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P2860
Unusual 1H NMR chemical shifts support (His) C(epsilon) 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis.
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2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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name
Unusual 1H NMR chemical shifts ...... in serine protease catalysis.
@ast
Unusual 1H NMR chemical shifts ...... in serine protease catalysis.
@en
type
label
Unusual 1H NMR chemical shifts ...... in serine protease catalysis.
@ast
Unusual 1H NMR chemical shifts ...... in serine protease catalysis.
@en
prefLabel
Unusual 1H NMR chemical shifts ...... in serine protease catalysis.
@ast
Unusual 1H NMR chemical shifts ...... in serine protease catalysis.
@en
P2093
P2860
P356
P1476
Unusual 1H NMR chemical shifts ...... in serine protease catalysis.
@en
P2093
D G Sanford
E M Bradshaw
E V Torchilin
J L Sudmeier
K C Haddad
W W Bachovchin
P2860
P304
10371-10376
P356
10.1073/PNAS.97.19.10371
P407
P577
2000-09-01T00:00:00Z