Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin
about
Detection of large pKa perturbations of an inhibitor and a catalytic group at an enzyme active site, a mechanistic basis for catalytic power of many enzymesInvolvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formationDeamination of 6-Aminodeoxyfutalosine in Menaquinone Biosynthesis by Distantly Related EnzymesPa0148 from Pseudomonas aeruginosa catalyzes the deamination of adenineAn energetic scale for equilibrium H/D fractionation factors illuminates hydrogen bond free energies in proteins.Unusual 1H NMR chemical shifts support (His) C(epsilon) 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis.Hydrogen-bonding partner of the proton-conducting histidine in the influenza M2 proton channel revealed from 1H chemical shiftsProton bridging in the interactions of thrombin with hirudin and its mimics.Proton bridging in the interactions of thrombin with small inhibitorsHigh-precision measurement of hydrogen bond lengths in proteins by nuclear magnetic resonance methods.Deuterium/hydrogen exchange factors measured by solution nuclear magnetic resonance spectroscopy as indicators of the structure and topology of membrane proteinsTransient intermediates in enzymology, 1964-2008.Serine protease acylation proceeds with a subtle re-orientation of the histidine ring at the tetrahedral intermediate.Catalytic role of enzymes: short strong H-bond-induced partial proton shuttles and charge redistributions.Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation FactorsTautomerism, acid-base equilibria, and H-bonding of the six histidines in subtilisin BPN' by NMRShort Hydrogen Bonds and Proton Delocalization in Green Fluorescent Protein (GFP)Deuterium solvent isotope effect and proton-inventory studies of factor Xa-catalyzed reactionsKinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.(15)N and (1)H Solid-State NMR Investigation of a Canonical Low-Barrier Hydrogen-Bond Compound: 1,8-Bis(dimethylamino)naphthalene.The EVB as a quantitative tool for formulating simulations and analyzing biological and chemical reactions.Ab initio molecular dynamics studies on HIV-1 reverse transcriptase triphosphate binding site: implications for nucleoside-analog drug resistance.Observation of a short, strong hydrogen bond in the active site of hydroxynitrile lyase from Hevea brasiliensis explains a large pKa shift of the catalytic base induced by the reaction intermediate.Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices.
P2860
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P2860
Fractionation factors and activation energies for exchange of the low barrier hydrogen bonding proton in peptidyl trifluoromethyl ketone complexes of chymotrypsin
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Fractionation factors and acti ...... tone complexes of chymotrypsin
@ast
Fractionation factors and acti ...... tone complexes of chymotrypsin
@en
type
label
Fractionation factors and acti ...... tone complexes of chymotrypsin
@ast
Fractionation factors and acti ...... tone complexes of chymotrypsin
@en
prefLabel
Fractionation factors and acti ...... tone complexes of chymotrypsin
@ast
Fractionation factors and acti ...... tone complexes of chymotrypsin
@en
P2093
P2860
P356
P1476
Fractionation factors and acti ...... tone complexes of chymotrypsin
@en
P2093
P2860
P304
14664-14668
P356
10.1073/PNAS.95.25.14664
P407
P577
1998-12-01T00:00:00Z