A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo - Wikidata - awgldk - TriplyDB

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo

http://www.wikidata.org/entity/Q34467166

about

Chemical probes of endocannabinoid metabolism Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants Fatty acid amide hydrolase inhibitors: a patent review (2009-2014)Design and synthesis of potent N-acylethanolamine-hydrolyzing acid amidase (NAAA) inhibitor as anti-inflammatory compounds Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats α-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications.Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence.Endocannabinoid tone versus constitutive activity of cannabinoid receptors.Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [(11)C]CURB.Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety.Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics follo Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats.Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives.Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors.Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.Enhancement of Anandamide-Mediated Endocannabinoid Signaling Corrects Autism-Related Social Impairment.Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT.Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor Synthesis and preclinical evaluation of [11C-carbonyl]PF-04457845 for neuroimaging of fatty acid amide hydrolase.O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors.Using molecular imaging to understand early schizophrenia-related psychosis neurochemistry: a review of human studies.Synthesis and application of isocyanates radiolabeled with carbon-11.

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P2860

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo

http://www.wikidata.org/entity/Q34467166

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

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2009年论文

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name

A second generation of carbama ...... with improved activity in vivo

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A second generation of carbama ...... with improved activity in vivo

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A second generation of carbama ...... with improved activity in vivo

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type

label

A second generation of carbama ...... with improved activity in vivo

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A second generation of carbama ...... with improved activity in vivo

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A second generation of carbama ...... with improved activity in vivo

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prefLabel

A second generation of carbama ...... with improved activity in vivo

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A second generation of carbama ...... with improved activity in vivo

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A second generation of carbama ...... with improved activity in vivo

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A second generation of carbama ...... with improved activity in vivo

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Alvin R King

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Andrea Duranti

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Andrea Tontini

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Claudia Silva

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Daniele Piomelli

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Giorgio Tarzia

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Jason R Clapper

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Silvano Sanchini

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P2860

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

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1505-1513

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scholarly article

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10.1002/CMDC.200900210

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9

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4

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Federica Vacondio

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2009-09-01T00:00:00Z

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26700150

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19637155

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3016090

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